Mobile Application for Patient Engagement and Physician-Directed Remote Management of Heart Failure

Inclusion Criteria:

• Diagnosis of heart failure

• Last left ventricular ejection fraction within 2 years < 50% based onechocardiogram, MRI, CT, or nuclear perfusion and, if no ejection fractiondocumented, then clinical documentation of heart failure with reduced ejectionfraction

• Currently admitted with upcoming discharge or discharged from hospital within theprior 4 weeks

• At least two eligible heart failure therapies (guideline-recommended BB, RASI, MRA,or SGLT2i) not yet initiated or at < 50% of target dose at time of enrollment

Exclusion Criteria:

• Receives dialysis

• Inotropic therapy after hospitalization

• History of a prior solid organ transplant or actively listed on heart transplantwaiting list

• History of left ventricular assist device implantation

• Cardiac amyloidosis

• Currently pregnant or intends to become pregnant during the study period

• Life expectancy estimated less than 6 months related to cardiac or non-cardiaccomorbidities as per investigator's judgment

• Actively enrolled in hospice or comfort care

• Currently participating in an investigational device or drug study or havingparticipated in such a study 30 days prior to screening

• Subject without a compatible smartphone

• Subject not proficient with written and spoken English

• Any other disorder or condition that, in the opinion of the investigator would posea risk to subject safety or interfere with the study evaluation, procedures orcompletion

• Participant has diminished decision-making capacity

• Admitted to or planned discharge to a skilled nursing facility or rehabilitationfacility (acute or subacute)