Drug-Eluting Balloon or Drug-Eluting Stent in Acute Myocardial Infarction: A Randomized Controlled Trial

Inclusion Criteria:

• Age >18 years with a life expectancy of >1 year;

• Patients fulfilling criteria for STEMI (>20 min of chest-pain; At least 1 mmST-elevation in at least two contiguous leads, a new left bundle branch block or atrue posterior myocardial infarction confirmed by ECG or echocardiography;Reperfusion is expected to be feasible within 12 h after onset of symptoms)

• Infarct related artery eligible for primary PCI (De novo lesion in a native coronaryartery; Reference-vessel diameter ≥2.5 mm and ≤ 4 mm; Absence of severecalcification; Residual diameter stenosis of ≤30% (by visual assessment) afterlesion preparation after lesion preparation; Absence of coronary dissection type ≥C.

Exclusion Criteria:

• Killip class>II on admission

• Known contraindication for aspirin, clopidogrel, ticagrelor, heparin or GP IIb/IIIainhibitor

• Previous myocardial infarction

• Previous PCI in the territory of the infarct-related artery (IRA)

• Previous CABG

• 3-vessel disease requiring revascularization

• Left-main disease

• Extremely angulated or severely calcified vessels

• History of ischemic stroke within the past 6 months or hemorrhagic stroke

• Planned CABG for a non-culprit vessel

• Participation in another investigational trial that has not completed its primaryendpoint or could interfere with the endpoints of this study