40 Hz Transcranial Alternating Current Stimulation for Inducing Gamma Oscillations

Last updated: December 24, 2024
Sponsor: The National Brain Mapping Laboratory (NBML)
Overall Status: Active - Recruiting

Phase

N/A

Condition

Memory Loss

Alzheimer's Disease

Mild Cognitive Impairment

Treatment

Sham Transcranial alternating current stimulation

Transcranial alternating current stimulation

Clinical Study ID

NCT06740864
IfADo_196_P3
  • Ages 50-85
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study aims to compare the efficacy of different 40 Hz tACS protocols in entraining gamma oscillations, which are linked to various cognitive functions and play a significant role in cognitive impairments like Alzheimer's disease. Specifically, it examines the effects of 40 Hz tACS applied to frontal brain regions versus fronto-temporal regions on gamma oscillations and working memory in healthy elderly individuals.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • healthy elderly between 50-80 years of age

  • normal or corrected to normal eye vision

  • right-handed

  • non-smokers

  • at least 70 % accuracy in working memory training task

Exclusion

Exclusion Criteria:

  • history of neurological or psychiatric disorders including seizures or epilepsy,

  • Taking CNS, blood pressure and other medications

  • having metal implants in the head and neck

  • significant cognitive decline meassured by The Montreal Cognitive Assessment (MoCA)

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: Sham Transcranial alternating current stimulation
Phase:
Study Start date:
June 01, 2024
Estimated Completion Date:
June 01, 2025

Connect with a study center

  • Institute for Research in Fundamental Sciences

    Tehran,
    Iran, Islamic Republic of

    Active - Recruiting

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