Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)

Last updated: December 13, 2024
Sponsor: Lille University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Exercise

Clinical Study ID

NCT06740136
2022-007
2022-A01308-35
  • Ages 18-35
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points. The investigators aim to include 300 participants in this research.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male or female

  • Aged between 18 and 35

  • Weighing more than 50 kg

  • Member of a sports club affiliated to an Olympic federation

  • Socially insured

  • Willing to comply with all study procedures and duration of the study

Exclusion

Exclusion Criteria:

  • Medical history contraindicating sporting activities

  • Current medical treatment

  • Not a member of a sports club affiliated to an Olympic federation

  • Administrative reasons: impossibility of receiving informed information,impossibility of participating in the entire study, absence of social securitycoverage, refusal to sign consent form.

Study Design

Total Participants: 300
Treatment Group(s): 1
Primary Treatment: Exercise
Phase:
Study Start date:
March 13, 2023
Estimated Completion Date:
December 19, 2025

Study Description

Elite-level sports expose athletes to training loads designed to induce muscle damage, aiming to achieve optimal physiological adaptations. However, the repetitive nature of such damage increases the risk of injury. The ability to assess an athlete's susceptibility to fragility is therefore crucial for optimizing their training and performance. Genetic factors appear to play a significant role in the occurrence of these injuries, particularly through subtle variations in DNA sequences. Depending on the location of these variations within a gene, they may or may not alter the expression or function of the associated protein. The investigators aimed to investigate the relationship between genetic polymorphisms and biological parameters in the context of exercise-induced muscle damage.

Connect with a study center

  • Eurasport

    Loos, 59120
    France

    Active - Recruiting

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