Allogeneic Use of Expanded Mesenchymal Stem Cells Derived From Adipose Tissue (HC106), Female Urinary Incontinence Women Over 50 Years Old

Inclusion Criteria:

• Women over 50 years old

• Women with a clinical diagnosis of genuine or mixed stress urinary incontinence (SUI) with at least 6 months of evolution. Using the definitions of urinaryincontinence internationally accepted by the ICS (International Continence Society):to. SUI: any involuntary loss of urine, immediately preceded by exertion. b. MixedUI: any involuntary loss of urine, immediately preceded by exertion or anuncontrollable desire to urinate.

The predominance of effort will be assessed when more than 50% of the patient's daily losses occur preceded by effort.

• Women in whom rehabilitative treatment has failed or patients who refuse to undergorehabilitative or surgical treatment

• Patients without active urinary tract infection (negative urine culture) at the timeof recruitment and treatment

• Signing of the informed consent form

Exclusion Criteria:

• Patients with a medical history of previous surgery for incontinence, prolapse orurological/gynecological/colorectal surgery

• Major surgery or serious trauma of the subject in the previous semester

• Women with mixed urinary incontinence, with predominant symptoms of urgency

• History of high-pressure detrusor overactivity

• Present infravesical obstruction, vesico-ureteral reflux or clinical history ofurinary fistula (it will be ruled out depending on the case by urethrocystoscopy,urethrocystography and flowmetry).

• Present any malignant neoplasm, unless it is basal cell or squamous cell carcinomaof the skin, or present a history of malignant tumors, unless they have been inremission during the previous 5 years.

• Cardiopulmonary disease that, in the opinion of the investigator, is unstable orserious enough to exclude the patient from the study.

• Medical or psychiatric illness of any type that, in the opinion of the researcher,may be a reason for exclusion from the study.

• History of alcohol or other addictive substance abuse in the 6 months prior toinclusion

• Subject's allergy to anesthetics