Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury

Last updated: January 20, 2025
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hemodialysis

Treatment

Intradialytic Cycling

Clinical Study ID

NCT06735378
15393
  • Ages 18-79
  • All Genders

Study Summary

The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment. Will pre-dialysis exercise protect the heart from a decrease in pumping of the heart muscle (called stunning) that can happen during hemodialysis. We will study whether pre-dialysis exercise decreases heart stunning, decreases the number and severity of symptoms commonly associated with hemodialysis, and other outcomes

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • must be on chronic hemodialysis for at least 3 months

  • age 18 years or older

  • willing and able to provide informed consent

  • assessed to be safe and able to exercise by unit HD Nephrologist

Exclusion

Exclusion Criteria:

  • regular vigorous exercise outside of hemodialysis

  • over 79 years of age

  • intradialytic exercise < 3 months

  • poor echogenicity

  • acute coronary syndrome in the past 3 months

  • unstable arrhythmia/angina

  • shortness of breath at rest or with minimal activity

  • symptomatic hypoglycemia (>2x/week in the week prior to enrolment)

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Intradialytic Cycling
Phase:
Study Start date:
January 20, 2025
Estimated Completion Date:
December 31, 2025

Study Description

This will be the first randomized crossover-controlled trial with two experimental conditions assessing the impact of exercise preconditioning in the HD population. If proven effective exercise preconditioning could be developed as a therapeutic option to reduce rates of heart failure in the dialysis population.

Connect with a study center

  • London Health Sciences Centre

    London, Ontario N6A 5W9
    Canada

    Active - Recruiting

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