Short Course Regimen in Low Risk Active Tuberculosis- a Multicenter, Randomized, Active-controlled, Trial

Inclusion Criteria:

• Newly diagnosed pulmonary tuberculosis patients combined with any of the followingdiagnostic conditions:

• at least one set of sputum specimens is positive for Mycobacterium tuberculosisculture or TB PCR test; or

• pathological and histological findings of typical tuberculosis manifestations;

• clinical diagnosis and Physician determines the need for completeanti-tuberculosis treatment

• Those who have had tuberculosis in the past and have been cured for at least threeyears can be included

• Aged over 20 years old

• Laboratory data at the time of inclusion in the study or within 14 days:

• Serum or plasma glutamic acid pyruvate transaminase (ALT) value ≦ three timesthe upper limit of normal

• Serum or plasma total bilirubin ≦ 2.5 times the upper limit of normal

• Serum or plasma creatinine ≦ twice the upper limit of normal or creatinineclearance greater than 30 mL/min

• Heme ≧7.0 g/Dl

• Platelets ≧100,000/mm3

• Patient signs consent form

• Patients who agree to join and cooperate with the county and city health bureau'surban treatment plan to ensure medication compliance.

Exclusion Criteria:

• The acid-fast smear of sputum or respiratory specimen is strongly positive (≥ 2+)

• Chest X-ray or lung computed tomography combined with open lesions

• Chest X-ray or lung computed tomography shows extensive lesions and the clinicianjudges that short-term treatment is not suitable

• Simultaneous combination of intrapulmonary and extrapulmonary tuberculosis

• People who are unable to take oral medications

• People who have participated in this research

• Have used anti-tuberculosis drugs for more than 14 days

• A history of tuberculosis suspected or diagnosed as central nervous systemtuberculosis, bone or joint tuberculosis, miliary tuberculosis or tuberculouspericarditis.

• Known history of allergy or intolerance to this study drug

• Patients with HIV infection, organ transplantation, and chronic renal failure

• Long-term use of immunosuppressive drugs, including steroid use >10mg/day (more than 30 consecutive days in the last three months)

• Late exclusion: Mycobacterium tuberculosis is known to be resistant to any one ormore of the following drugs: rifampin, isoniazid, ethambutol