UmbREALung - A Retrospective and Prospective, Observational, Real World Multi-cohort Study of Patients With Non-small Cell Lung Cancer (NSCLC) Initiating Approved Drugs Developed by AZ or as Part of an AZ Alliance

Last updated: April 9, 2025
Sponsor: AstraZeneca
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06726720
D4191R00060
  • Ages > 18
  • All Genders

Study Summary

This is an ambispective, observational, multicenter and multicohort study, targeting patients with NSCLC initiating approved drugs developed by AZ or as part of an AZ alliance, in the participating countries, as monotherapy or in combination at any stage of disease. Three cohorts are designed, based on the stage of NSCLC (resectable, unresectable and metastatic). The multicohort study is modular in design. Specific modules will be set up separately to assess each new indication of drugs developed by AZ or as part of an AZ alliance once European marketing authorization (MA) has been granted and made available in the participating countries.

Patients will be enrolled in the study if they have received (retrospective), receive (retrospective and prospective) or will receive (prospective) approved drugs developed by AZ or as part of an AZ alliance according to the eligibility criteria.

Treatment plan and decision are made independently by each treating physician prior to inclusion in this study.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients (≥ 18 years old)

  • Patients with histologically or cytologically proven NSCLC

  • Patients initiated with approved drugs developed by AZ or as part of an AZ allianceat the time of the enrollment or within the previous three weeks.

  • Informed patients who consent to participate in the study as per local regulations.

Exclusion

Exclusion Criteria:

  • Patients participating in an interventional clinical trial for NSCLC*
  • with the exception on low-interventional studies (RIPH2) where the interventiondoes not involve the NSCLC treatment
  • Patients already enrolled in another module of the cohort in UMBREALUNG

  • Patients under safeguard of justice, curatorship or guardianship

Study Design

Total Participants: 300
Study Start date:
December 16, 2024
Estimated Completion Date:
June 30, 2032

Connect with a study center

  • Research Site

    Aix En Provence, 13100
    France

    Site Not Available

  • Research Site

    Aurillac, 15000
    France

    Active - Recruiting

  • Research site

    Aurillac,
    France

    Active - Recruiting

  • Research Site

    Blois, 41016
    France

    Active - Recruiting

  • Research Site

    Chalon sur Saone, 71321
    France

    Site Not Available

  • Research Site

    Chambery, 73000
    France

    Active - Recruiting

  • Research site

    Chambery,
    France

    Active - Recruiting

  • Research Site

    Creteil, 94000
    France

    Active - Recruiting

  • Research Site

    Dieppe, 76202
    France

    Site Not Available

  • Research Site

    Dinan, 22100
    France

    Site Not Available

  • Research Site

    Le COUDRAY, 28630
    France

    Site Not Available

  • Research Site

    Meaux, 77100
    France

    Site Not Available

  • Research Site

    Metz, 57000
    France

    Site Not Available

  • Research Site

    Mulhouse, 68100
    France

    Active - Recruiting

  • Research Site

    Nancy, 54100
    France

    Active - Recruiting

  • Research Site

    Nice, 06000
    France

    Site Not Available

  • Research Site

    Perpignan, 66000
    France

    Site Not Available

  • Research Site

    St Brieuc, 22000
    France

    Active - Recruiting

  • Research Site

    St Etienne, 42100
    France

    Active - Recruiting

  • Research Site

    St Herblain, 44800
    France

    Site Not Available

  • Research Site

    Troyes, 10000
    France

    Site Not Available

  • Research Site

    Valenciennes, 59300
    France

    Active - Recruiting

  • Research Site

    Villeurbanne, 69100
    France

    Active - Recruiting

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