UmbREALung - A Retrospective and Prospective, Observational, Real World Multi-cohort Study of Patients With Non-small Cell Lung Cancer (NSCLC) Initiating Approved Drugs Developed by AZ or as Part of an AZ Alliance

Last updated: March 19, 2026
Sponsor: AstraZeneca
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06726720
D4191R00060
  • Ages > 18
  • All Genders

Study Summary

This is an ambispective, observational, multicenter and multicohort study, targeting patients with NSCLC initiating approved drugs developed by AZ or as part of an AZ alliance, in the participating countries, as monotherapy or in combination at any stage of disease. Three cohorts are designed, based on the stage of NSCLC (resectable, unresectable and metastatic). The multicohort study is modular in design. Specific modules will be set up separately to assess each new indication of drugs developed by AZ or as part of an AZ alliance once European marketing authorization (MA) has been granted and made available in the participating countries.

Patients will be enrolled in the study if they have received (retrospective), receive (retrospective and prospective) or will receive (prospective) approved drugs developed by AZ or as part of an AZ alliance according to the eligibility criteria.

Treatment plan and decision are made independently by each treating physician prior to inclusion in this study.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients (≥ 18 years old)

  • Patients with histologically or cytologically proven NSCLC

  • Patients initiated with approved drugs developed by AZ or as part of an AZ allianceat the time of the enrollment or within the previous three weeks.

  • Informed patients who consent to participate in the study as per local regulations.

Exclusion

Exclusion Criteria:

  • Patients participating in an interventional clinical trial for NSCLC*
  • with the exception on low-interventional studies (RIPH2) where the interventiondoes not involve the NSCLC treatment
  • Patients already enrolled in another module of the cohort in UMBREALUNG

  • Patients under safeguard of justice, curatorship or guardianship

Study Design

Total Participants: 300
Study Start date:
December 16, 2024
Estimated Completion Date:
June 30, 2032

Connect with a study center

  • Research Site

    Aix En Provence, 13100
    France

    Site Not Available

  • Research Site

    Aix-en-Provence, 13100
    France

    Active - Recruiting

  • Research Site

    Aix-en-Provence 3038354,
    France

    Site Not Available

  • Research Site

    Angers, 49933
    France

    Active - Recruiting

  • Research Site

    Angers 3037656,
    France

    Site Not Available

  • Research Site

    Aurillac, 15000
    France

    Active - Recruiting

  • Research site

    Aurillac,
    France

    Active - Recruiting

  • Research Site

    Aurillac 3036016,
    France

    Site Not Available

  • Research Site

    Auxerre, 89000
    France

    Active - Recruiting

  • Research Site

    Auxerre 3035843,
    France

    Site Not Available

  • Research Site

    Avignon, 84918
    France

    Active - Recruiting

  • Research Site

    Avignon 3035681,
    France

    Site Not Available

  • Research Site

    Bezannes, 51430
    France

    Site Not Available

  • Research Site

    Blois, 41016
    France

    Active - Recruiting

  • Research Site

    Blois 3032213,
    France

    Site Not Available

  • Research Site

    Bordeaux, 33000
    France

    Active - Recruiting

  • Research Site

    Bordeaux 3031582,
    France

    Site Not Available

  • Research Site

    Bourg En Bresse,
    France

    Site Not Available

  • Research Site

    Bourg-en-Bresse, 01012
    France

    Active - Recruiting

  • Research Site

    Bourg-en-Bresse 3031009,
    France

    Site Not Available

  • Research Site

    Béziers, 34500
    France

    Site Not Available

  • Research Site

    Caen, 14052
    France

    Site Not Available

  • Research Site

    Carcassonne, 11010
    France

    Active - Recruiting

  • Research Site

    Carcassonne 3028641,
    France

    Site Not Available

  • Research Site

    Chalon Sur Sa Ne, 71321
    France

    Active - Recruiting

  • Research Site

    Chalon sur Saone, 71321
    France

    Site Not Available

  • Research Site

    Chalon-sur-Saône 3027484,
    France

    Site Not Available

  • Research Site

    Chambery, 73000
    France

    Site Not Available

  • Research site

    Chambery,
    France

    Active - Recruiting

  • Research Site

    Chambéry, 73000
    France

    Active - Recruiting

  • Research Site

    Chambéry 3027422,
    France

    Site Not Available

  • Research Site

    Chateauroux,
    France

    Site Not Available

  • Research Site

    Châteauroux, 36019
    France

    Active - Recruiting

  • Research Site

    Châteauroux 3026204,
    France

    Site Not Available

  • Research Site

    Creteil, 94000
    France

    Site Not Available

  • Research Site

    Créteil, 94000
    France

    Active - Recruiting

  • Research Site

    Créteil 3022530,
    France

    Site Not Available

  • Research Site

    Dieppe, 76202
    France

    Active - Recruiting

  • Research Site

    Dieppe 3021411,
    France

    Site Not Available

  • Research Site

    Dinan, 22100
    France

    Active - Recruiting

  • Research Site

    Dinan 3021356,
    France

    Site Not Available

  • Research Site

    Dreux, 28102
    France

    Active - Recruiting

  • Research Site

    Dreux 3020810,
    France

    Site Not Available

  • Research Site

    Epagny METZ Tessy, 74370
    France

    Active - Recruiting

  • Research Site

    Epagny Metz Tessy,
    France

    Site Not Available

  • Research Site

    Fort de France Cedex, 97200
    France

    Active - Recruiting

  • Research Site

    Le Coudray, 28630
    France

    Active - Recruiting

  • Research Site

    Le Coudray 3004471,
    France

    Site Not Available

  • Research Site

    Limoges, 87000
    France

    Active - Recruiting

  • Research Site

    Limoges 2998286,
    France

    Site Not Available

  • Research Site

    Lyon, 69437
    France

    Active - Recruiting

  • Research Site

    Lyon 2996944,
    France

    Site Not Available

  • Research Site

    Marseille, 13003
    France

    Active - Recruiting

  • Research Site

    Marseille 2995469,
    France

    Site Not Available

  • Research Site

    Meaux, 77100
    France

    Active - Recruiting

  • Research Site

    Meaux 2994798,
    France

    Site Not Available

  • Research Site

    Metz, 57070
    France

    Active - Recruiting

  • Research Site

    Metz 2994160,
    France

    Site Not Available

  • Research Site

    Mulhouse, 68100
    France

    Active - Recruiting

  • Research Site

    Mulhouse 2991214,
    France

    Site Not Available

  • Research Site

    N MES, 30029
    France

    Active - Recruiting

  • Research Site

    Nancy, 54100
    France

    Active - Recruiting

  • Research Site

    Nancy 2990999,
    France

    Site Not Available

  • Research Site

    Nantes, 44200
    France

    Active - Recruiting

  • Research Site

    Nantes 2990969,
    France

    Site Not Available

  • Research Site

    Neuilly-sur-Seine, 92200
    France

    Active - Recruiting

  • Research Site

    Neuilly-sur-Seine 2990611,
    France

    Site Not Available

  • Research Site

    Nice, 06000
    France

    Active - Recruiting

  • Research Site

    Nice 2990440,
    France

    Site Not Available

  • Research Site

    Nimes, 30029
    France

    Site Not Available

  • Research Site

    Nîmes 2990363,
    France

    Site Not Available

  • Research Site

    Perpignan, 66000
    France

    Active - Recruiting

  • Research Site

    Perpignan 2987914,
    France

    Site Not Available

  • Research Site

    Reims, 51726
    France

    Site Not Available

  • Research Site

    Rouen, 76000
    France

    Site Not Available

  • Research Site

    Saint-Brieuc, 22000
    France

    Active - Recruiting

  • Research Site

    Saint-Brieuc 2981280,
    France

    Site Not Available

  • Research Site

    Saint-Etienne, 42100
    France

    Active - Recruiting

  • Research Site

    Saint-Etienne 2980291,
    France

    Site Not Available

  • Research Site

    Saint-Herblain, 44800
    France

    Active - Recruiting

  • Research Site

    Saint-Herblain 2979590,
    France

    Site Not Available

  • Research Site

    Saint-Priest-en-Jarez, 42271
    France

    Site Not Available

  • Research Site

    St Brieuc, 22000
    France

    Site Not Available

  • Research Site

    St Etienne, 42100
    France

    Site Not Available

  • Research Site

    St Herblain, 44800
    France

    Site Not Available

  • Research Site

    Strasbourg, 67000
    France

    Active - Recruiting

  • Research Site

    Suresnes, 92151
    France

    Active - Recruiting

  • Research Site

    Suresnes 2973675,
    France

    Site Not Available

  • Research Site

    Toulouse, 31076
    France

    Active - Recruiting

  • Research Site

    Toulouse 2972315,
    France

    Site Not Available

  • Research Site

    Troyes, 10000
    France

    Site Not Available

  • Research Site

    Troyes 2971549,
    France

    Site Not Available

  • Research Site

    VILLEFRANCHE SUR SAONE Cedex,
    France

    Site Not Available

  • Research Site

    Valenciennes, 59300
    France

    Active - Recruiting

  • Research Site

    Valenciennes 2971041,
    France

    Site Not Available

  • Research Site

    Vandœuvre-lès-Nancy, 54519
    France

    Site Not Available

  • Research Site

    Vannes, 56017
    France

    Active - Recruiting

  • Research Site

    Vannes 2970777,
    France

    Site Not Available

  • Research Site

    Villefranche-sur-Saône, 69655
    France

    Active - Recruiting

  • Research Site

    Villefranche-sur-Saône 2968748,
    France

    Site Not Available

  • Research Site

    Villeurbanne, 69100
    France

    Active - Recruiting

  • Research Site

    Villeurbanne 2968254,
    France

    Site Not Available

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