High Definition Transcranial Direct Current Stimulation of Right Inferior Frontal Gyrus to Improve Social Impairments in Children with Autism

Last updated: December 17, 2024
Sponsor: Central South University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Williams Syndrome

Autism

Asperger's Disorder

Treatment

Sham (No Treatment)

HD-tDCS

Clinical Study ID

NCT06723522
LYEC2024-0306
  • Ages 3-18
  • All Genders

Study Summary

The goal of this clinical trial is to learn if high definition transcranial direct current stimulation (HD-tDCS) of right inferior frontal gyrus works to improve social impairments in children with autism spectrum disorder (ASD). It will also learn about the underlying brain mechanism. The main questions it aims to answer are:

  • Does HD-tDCS of right inferior frontal gyrus improve social impairments in children with ASD?

  • What are the underlying brain mechanisms by which the HD-tDCS of right inferior frontal gyrus improves social impairments in children with ASD? Researchers will compare participants received active HD-tDCS to controls received sham HD-tDCS (performed to mimic the sensation induced by real HD-tDCS before and after the stimulation) to see if HD-tDCS of right inferior frontal gyrus improves social impairments in children with ASD.

Participants will:

  • Receive a dose of 2 mA HD-tDCS of right inferior frontal gyrus lasting for 10 days.

  • Receive social functioning assessment, functional near-infrared spectroscopy and electroencephalography measurement before and after stimulation

  • Visit the clinic once every 2 weeks for checkups and tests, a total of 2 times.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • had to be 3-18 years old; be diagnosed with ASD (according to the Diagnostic andStatistical Manual of Mental Disorders (DSM-5) and Autism Diagnostic Interview -Revised (ADI-R).

Exclusion

Exclusion Criteria:

  • with other comorbid neuropsychiatric conditions (i.e., schizophrenia spectrumdisorders and mood disorders) or neurological disorders (i.e., head trauma andepilepsy).

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Sham (No Treatment)
Phase:
Study Start date:
August 30, 2024
Estimated Completion Date:
July 31, 2026

Connect with a study center

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan 410011
    China

    Active - Recruiting

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