A Randomized Comparison of Personalized Therapy Mgmt Based On Coronary Atherosclerotic Plaque Vs. Usual Care for Symptomatic Patients With Suspicion of CAD

Inclusion Criteria:

• > 18 years

• Symptomatic patients with suspicion of CAD, including those referred for elective,non-urgent diagnostic testing (e.g. stress test)

Exclusion Criteria:

• LDL < 100 mg/dL

• Currently or previously treated beyond primary prevention guidelines

• Suspected acute coronary syndrome or otherwise unstable clinical status

• Planned cardiovascular procedure (e.g. coronary angiography, cardiac surgery,non-coronary vascular procedure)

• Noninvasive or invasive CV testing for CAD within 1 year (e.g. invasive coronaryangiography (ICA), coronary CT angiography (CCTA) including calcium scoring)

• Known history of obstructive CAD (prior myocardial infarction, CABG or PCI, stenosis ≥50%)

• Known EF ≤40% or other moderate to severe valvular or congenital cardiac disease

• Contraindications to CCTA