A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING

Last updated: November 19, 2025
Sponsor: AbbVie
Overall Status: Active - Recruiting

Phase

N/A

Condition

Rheumatoid Arthritis

Joint Injuries

Treatment

N/A

Clinical Study ID

NCT06712628
P25-188
  • Ages > 18
  • All Genders

Study Summary

This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care

This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or TNFi therapy. Around 678 participants will be enrolled in approximately 80 sites in Germany.

Study recruitment will last approximately 24 months, and the study participation time will be up to 24 months, for a total study duration of approximately 48 months.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Current or Past participants with a confirmed diagnosis of moderate to severe activeRA upon judgement of the treating physician.

  • Physician decision on participant treatment with Upadacitinib (UPA) or tumornecrosis factor inhibitor (TNFi) must have been reached prior to and independentlyof recruitment in the study

  • UPA or TNFi prescribed in accordance with the applicable approved label and localregulatory and reimbursement policies

Exclusion

Exclusion Criteria:

  • Participation in a clinical trial with an investigational drug (within a minimum of 30 days or 5 half-lives of the investigational drug [whichever is longer] prior tobaseline)

  • Prior treatment with Upadacitinib

  • Prior treatment with the same tumor necrosis factor inhibitor as the one prescribedfor this study

Study Design

Total Participants: 678
Study Start date:
November 07, 2024
Estimated Completion Date:
December 31, 2028

Connect with a study center

  • Rheumapraxis Heidelberg /ID# 276475

    Heidelberg, Baden-Wuerttemberg 69120
    Germany

    Site Not Available

  • Rheumapraxis Haas Tübingen /ID# 275536

    Tuebingen, Baden-Wuerttemberg 72072
    Germany

    Site Not Available

  • Rheumapraxis Ulm Dr. med. Nadia Rinaldi /ID# 276293

    Ulm, Baden-Wuerttemberg 89073
    Germany

    Site Not Available

  • Gemeinschaftspraxis Innere Medizin/Rheumatologie /ID# 278584

    Freiburg im Breisgau 2925177, Baden-Wurttemberg 2953481 79098
    Germany

    Active - Recruiting

  • Rheumapraxis Heidelberg /ID# 276475

    Heidelberg 2907911, Baden-Wurttemberg 2953481 69120
    Germany

    Active - Recruiting

  • Rheumapraxis Haas Tübingen /ID# 275536

    Tübingen 2820860, Baden-Wurttemberg 2953481 72072
    Germany

    Active - Recruiting

  • Rheumapraxis Ulm Dr. med. Nadia Rinaldi /ID# 276293

    Ulm 2820256, Baden-Wurttemberg 2953481 89073
    Germany

    Active - Recruiting

  • Dr. Med. Thomas Marycz /ID# 274646

    Amberg 2956656, Bavaria 2951839 92224
    Germany

    Active - Recruiting

  • Rheumapraxis Am Webereck /ID# 274412

    Augsburg 2954172, Bavaria 2951839 86157
    Germany

    Active - Recruiting

  • Dr. Harmuth /ID# 273401

    Marktredwitz 2873289, Bavaria 2951839 95615
    Germany

    Active - Recruiting

  • Praxiszentrum Dr. Med. Klaus Krüger Dres. Günther Kellerer Und Paul Kellerer /ID# 276138

    Munich 2867714, Bavaria 2951839 81541
    Germany

    Active - Recruiting

  • Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587

    Planegg 2853463, Bavaria 2951839 82152
    Germany

    Active - Recruiting

  • Dr. Med. Thomas Marycz /ID# 274646

    Amberg, Bayern 92224
    Germany

    Site Not Available

  • Rheumapraxis Am Webereck /ID# 274412

    Augsburg, Bayern 86157
    Germany

    Site Not Available

  • Dr. Harmuth /ID# 273401

    Marktredwitz, Bayern 95615
    Germany

    Site Not Available

  • Praxiszentrum Dr. Med. Klaus Krüger Dres. Günther Kellerer Und Paul Kellerer /ID# 276138

    Munich, Bayern 81541
    Germany

    Site Not Available

  • Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587

    Planegg, Bayern 82152
    Germany

    Site Not Available

  • Private Practice - Dr. Dirk Wernicke /ID# 276820

    Hohen Neuendorf, Brandenburg 16540
    Germany

    Site Not Available

  • Rheumahaus Studien GbR /ID# 275917

    Potsdam, Brandenburg 14467
    Germany

    Site Not Available

  • Rheumatologisch Immunologisch /ID# 275830

    Templin, Brandenburg 17268
    Germany

    Site Not Available

  • Private Practice - Dr. Dirk Wernicke /ID# 276820

    Hohen Neuendorf 2901588, Brandenburg 2945356 16540
    Germany

    Active - Recruiting

  • Praxis K. Pagel /ID# 279121

    Hoppegarten 2899172, Brandenburg 2945356 15366
    Germany

    Active - Recruiting

  • Rheumahaus Studien GbR /ID# 275917

    Potsdam 2852458, Brandenburg 2945356 14467
    Germany

    Active - Recruiting

  • Rheumatologisch Immunologisch /ID# 275830

    Templin 2823533, Brandenburg 2945356 17268
    Germany

    Active - Recruiting

  • Rheumatism Center Mittelhessen /ID# 274641

    Bad Endenbach, Hesse 2905330 35080
    Germany

    Active - Recruiting

  • Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291

    Frankfurt am Main 2925533, Hesse 2905330 60329
    Germany

    Active - Recruiting

  • Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291

    Frankfurt am Main, Hessen 60329
    Germany

    Site Not Available

  • Praxis. F. Bigdeli-Wilshusen /ID# 273455

    Hanover 2910831, Lower Saxony 2862926 30173
    Germany

    Active - Recruiting

  • Rheumapraxis Hannover-List /ID# 273735

    Hanover 2910831, Lower Saxony 2862926 30161
    Germany

    Active - Recruiting

  • Rheumatologie Kassel /ID# 275916

    Kassel, Lower Saxony 2862926 34125
    Germany

    Active - Recruiting

  • Rheumapraxis An Der Hase /ID# 276949

    Osnabrück 2856883, Lower Saxony 2862926 49074
    Germany

    Active - Recruiting

  • Fachpraxis für Rheumatologie und Osteologie /ID# 275359

    Weyhe 2809835, Lower Saxony 2862926 28844
    Germany

    Active - Recruiting

  • Private Practice - Dr. Thilo Klopsch - Stargarder Strasse /ID# 276367

    Neubrandenburg, Mecklenburg-Vorpommern 17033
    Germany

    Site Not Available

  • Private Practice - Dr. Thilo Klopsch - Stargarder Strasse /ID# 276367

    Neubrandenburg 2866135, Mecklenburg-Vorpommern 2872567 17033
    Germany

    Active - Recruiting

  • Praxis. F. Bigdeli-Wilshusen /ID# 273455

    Hanover, Niedersachsen 30173
    Germany

    Active - Recruiting

  • Rheumapraxis Hannover-List /ID# 273735

    Hanover, Niedersachsen 30161
    Germany

    Site Not Available

  • Rheumapraxis An Der Hase /ID# 276949

    Osnabrück, Niedersachsen 49074
    Germany

    Site Not Available

  • Fachpraxis für Rheumatologie und Osteologie /ID# 275359

    Weyhe, Niedersachsen 28844
    Germany

    Site Not Available

  • Rheumazentrum Ruhrgebiet /ID# 275518

    Herne, Nordrhein-Westfalen 44649
    Germany

    Site Not Available

  • Rheumazentrum Ratingen /ID# 275707

    Ratingen, Nordrhein-Westfalen 40882
    Germany

    Site Not Available

  • Rheumazentrum Ruhrgebiet /ID# 275518

    Herne 2905891, North Rhine-Westphalia 2861876 44649
    Germany

    Active - Recruiting

  • St.Elisabeth Hospital Meerbusch /ID# 275030

    Meerbusch 2872504, North Rhine-Westphalia 2861876 40668
    Germany

    Active - Recruiting

  • Rheumazentrum Ratingen /ID# 275707

    Ratingen 2850174, North Rhine-Westphalia 2861876 40882
    Germany

    Active - Recruiting

  • Praxis Dr. med. Florian Beyer /ID# 274293

    Kaiserslautern, Rheinland-Pfalz 67657
    Germany

    Site Not Available

  • Praxis Dr. med. Florian Beyer /ID# 274293

    Kaiserslautern 2894003, Rhineland-Palatinate 2847618 67657
    Germany

    Active - Recruiting

  • Rheumapraxis am Schlossberg /ID# 272728

    Homburg, Saarland 66424
    Germany

    Site Not Available

  • Dr. Murawski /ID# 272724

    Neunkirchen, Saarland 66538
    Germany

    Site Not Available

  • Rheumapraxis am Schlossberg /ID# 272728

    Homburg 2899449, Saarland 2842635 66424
    Germany

    Active - Recruiting

  • Dr. Murawski /ID# 272724

    Neunkirchen 2864435, Saarland 2842635 66538
    Germany

    Active - Recruiting

  • Knappschaftsklinikum Saar /ID# 279852

    Püttlingen 2851584, Saarland 2842635 66346
    Germany

    Active - Recruiting

  • Rheumapraxis Dr. Prothmann /ID# 279851

    Püttlingen 2851584, Saarland 2842635 66346
    Germany

    Active - Recruiting

  • Medizinischen Versorgungszentrums Agilomed /ID# 274887

    Chemnitz, Sachsen 09130
    Germany

    Site Not Available

  • Dr. Mueller /ID# 273081

    Freiberg, Sachsen 09599
    Germany

    Site Not Available

  • Private Practice - Dr. Frank Hamann, Dr. Andreas Teich & Dr. Konrad Boche /ID# 275358

    Leipzig, Sachsen 04109
    Germany

    Active - Recruiting

  • Private Practice - Dr. Ilka Schwarze /ID# 276981

    Leipzig, Sachsen 04129
    Germany

    Site Not Available

  • Private Practice - Dr. Christine Baumann /ID# 275095

    Plauen, Sachsen 08523
    Germany

    Site Not Available

  • Praxis H. Fricke-Wagner /ID# 274467

    Zwickau, Sachsen 08056
    Germany

    Site Not Available

  • Rheumapraxis Dr. Liebhaber /ID# 274888

    Halle, Sachsen-Anhalt 06128
    Germany

    Site Not Available

  • Rheumatologische Facharztpraxis /ID# 272866

    Magdeburg, Sachsen-Anhalt 39104
    Germany

    Site Not Available

  • Medizinischen Versorgungszentrums Agilomed /ID# 274887

    Chemnitz 2940132, Saxony 2842566 09130
    Germany

    Active - Recruiting

  • Dr. Mueller /ID# 273081

    Freiberg 2925192, Saxony 2842566 09599
    Germany

    Active - Recruiting

  • Private Practice - Dr. Frank Hamann, Dr. Andreas Teich & Dr. Konrad Boche /ID# 275358

    Leipzig 2879139, Saxony 2842566 04109
    Germany

    Active - Recruiting

  • Private Practice - Dr. Ilka Schwarze /ID# 276981

    Leipzig 2879139, Saxony 2842566 04129
    Germany

    Active - Recruiting

  • Private Practice - Dr. Christine Baumann /ID# 275095

    Plauen 2853292, Saxony 2842566 08523
    Germany

    Active - Recruiting

  • Praxis H. Fricke-Wagner /ID# 274467

    Zwickau 2803560, Saxony 2842566 08056
    Germany

    Active - Recruiting

  • Rheumapraxis Dr. Liebhaber /ID# 274888

    Halle 2911522, Saxony-Anhalt 2842565 06128
    Germany

    Active - Recruiting

  • Rheumatologische Facharztpraxis /ID# 272866

    Magdeburg 2874545, Saxony-Anhalt 2842565 39104
    Germany

    Active - Recruiting

  • Private Practice - Dr. Jochen Walter /ID# 280069

    Rendsburg 2848245, Schleswig-Holstein 2838632 24768
    Germany

    Site Not Available

  • Private Practice - Dr. Thomas Kupka /ID# 273631

    Altenburg, Thueringen 04600
    Germany

    Site Not Available

  • Rheumazentrum Kupka /ID# 273631

    Altenburg, Thueringen 04600
    Germany

    Active - Recruiting

  • Rheumapraxis Weimar /ID# 272740

    Weimar, Thueringen 99427
    Germany

    Site Not Available

  • Private Practice - Dr. Thomas Kupka /ID# 273631

    Altenburg 2957773, Thuringia 2822542 04600
    Germany

    Active - Recruiting

  • Rheumapraxis Weimar /ID# 272740

    Weimar 2812482, Thuringia 2822542 99427
    Germany

    Active - Recruiting

  • MVZ Weserbergland /ID# 276009

    Bad Pyrmont, 31812
    Germany

    Site Not Available

  • MVZ Weserbergland /ID# 276009

    Bad Pyrmont 2953379, 31812
    Germany

    Completed

  • Private Practice - Dr. Silke Zinke /ID# 276366

    Berlin, 13055
    Germany

    Site Not Available

  • Private Practice - Dr. Silke Zinke /ID# 276366

    Berlin 2950159, 13055
    Germany

    Active - Recruiting

  • MVZ Herzogin Elisabeth Hospital /ID# 272725

    Braunschweig 2945024, 38114
    Germany

    Active - Recruiting

  • MVZ Herzogin Elisabeth Hospital /ID# 272725

    Brunswick, 38114
    Germany

    Site Not Available

  • Dres. Schuh /ID# 272731

    Coburg, 96450
    Germany

    Active - Recruiting

  • Private Practice - Dr. Sebastian Schuh /ID# 272731

    Coburg, 96450
    Germany

    Site Not Available

  • Private Practice - Dr. Sebastian Schuh /ID# 272731

    Coburg 2939951, 96450
    Germany

    Active - Recruiting

  • Rheumapraxis Düren /ID# 272726

    Düren, 52355
    Germany

    Site Not Available

  • Rheumapraxis Düren /ID# 272726

    Düren 2934486, 52355
    Germany

    Active - Recruiting

  • Praxis Dilltal /ID# 272727

    Ehringshausen, 35630
    Germany

    Site Not Available

  • Praxis Dilltal /ID# 272727

    Ehringshausen 2932788, 35630
    Germany

    Active - Recruiting

  • Dr. Bestler /ID# 272741

    Erfurt, 99096
    Germany

    Active - Recruiting

  • Private Practice - Dr. Daniel Bestler /ID# 272741

    Erfurt, 99096
    Germany

    Site Not Available

  • Private Practice - Dr. Daniel Bestler /ID# 272741

    Erfurt 2929670, 99096
    Germany

    Active - Recruiting

  • Praxis Fiene /ID# 279410

    Greifswald 2917788, 17493
    Germany

    Active - Recruiting

  • Private Practice - Dr. Hauke E. Heintz /ID# 278081

    Hamburg, 22391
    Germany

    Site Not Available

  • Private Practice - Dr. Hauke E. Heintz /ID# 278081

    Hamburg 2911298, 22391
    Germany

    Active - Recruiting

  • Rheumatologische Facharztpraxis /ID# 272743

    Naumburg 2866906, 06618
    Germany

    Active - Recruiting

  • Rheumatologische Facharztpraxis /ID# 272743

    Naumburg (Saale), 06618
    Germany

    Site Not Available

  • Cellitinnen-Krankenhaus St. Josef /ID# 275926

    Wuppertal, 42105
    Germany

    Active - Recruiting

  • Praxis Barmen /ID# 277514

    Wuppertal, 42285
    Germany

    Site Not Available

  • Cellitinnen-Krankenhaus St. Josef /ID# 275926

    Wuppertal 2805753, 42105
    Germany

    Active - Recruiting

  • Praxis Barmen /ID# 277514

    Wuppertal 2805753, 42285
    Germany

    Active - Recruiting

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