A Comparison Study of Persistence of UPadacitinib Vs. TNF-inhibitoRs in a German Real-world SettING

Last updated: March 14, 2025
Sponsor: AbbVie
Overall Status: Active - Recruiting

Phase

N/A

Condition

Joint Injuries

Rheumatoid Arthritis

Treatment

N/A

Clinical Study ID

NCT06712628
P25-188
  • Ages > 18
  • All Genders

Study Summary

This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care

This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or TNFi therapy. Around 678 participants will be enrolled in approximately 80 sites in Germany.

Study recruitment will last approximately 24 months, and the study participation time will be up to 24 months, for a total study duration of approximately 48 months.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Current or Past participants with a confirmed diagnosis of moderate to severe activeRA upon judgement of the treating physician.

  • Physician decision on participant treatment with Upadacitinib (UPA) or tumornecrosis factor inhibitor (TNFi) must have been reached prior to and independentlyof recruitment in the study

  • UPA or TNFi prescribed in accordance with the applicable approved label and localregulatory and reimbursement policies

Exclusion

Exclusion Criteria:

  • Participation in a clinical trial with an investigational drug (within a minimum of 30 days or 5 half-lives of the investigational drug [whichever is longer] prior tobaseline)

  • Prior treatment with Upadacitinib

  • Prior treatment with the same tumor necrosis factor inhibitor as the one prescribedfor this study

Study Design

Total Participants: 678
Study Start date:
November 07, 2024
Estimated Completion Date:
December 31, 2028

Connect with a study center

  • Rheumapraxis Haas Tübingen /ID# 275536

    Tuebingen, Baden-Wuerttemberg 72072
    Germany

    Active - Recruiting

  • Dr. Med. Thomas Marycz /ID# 274646

    Amberg, Bayern 92224
    Germany

    Active - Recruiting

  • Rheumapraxis Am Webereck /ID# 274412

    Augsburg, Bayern 86157
    Germany

    Active - Recruiting

  • Dr. Harmuth /ID# 273401

    Marktredwitz, Bayern 95615
    Germany

    Active - Recruiting

  • Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587

    Planegg, Bayern 82152
    Germany

    Active - Recruiting

  • Rheumahaus Studien GbR /ID# 275917

    Potsdam, Brandenburg 14467
    Germany

    Site Not Available

  • Rheumatologisch Immunologisch /ID# 275830

    Templin, Brandenburg 17268
    Germany

    Active - Recruiting

  • Rheumatism Center Mittelhessen /ID# 274641

    Bad Endenbach, Hessen 35080
    Germany

    Active - Recruiting

  • Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291

    Frankfurt am Main, Hessen 60329
    Germany

    Active - Recruiting

  • Praxis. F. Bigdeli-Wilshusen /ID# 273455

    Hanover, Niedersachsen 30173
    Germany

    Active - Recruiting

  • Rheumapraxis Hannover-List /ID# 273735

    Hanover, Niedersachsen 30161
    Germany

    Active - Recruiting

  • Rheumatologie Kassel /ID# 275916

    Kassel, Niedersachsen 34125
    Germany

    Site Not Available

  • Fachpraxis für Rheumatologie und Osteologie /ID# 275359

    Weyhe, Niedersachsen 28844
    Germany

    Active - Recruiting

  • Rheumazentrum Ruhrgebiet /ID# 275518

    Herne, Nordrhein-Westfalen 44649
    Germany

    Active - Recruiting

  • Rheumazentrum Ratingen /ID# 275707

    Ratingen, Nordrhein-Westfalen 40882
    Germany

    Site Not Available

  • Praxis Dr. med. Florian Beyer /ID# 274293

    Kaiserslautern, Rheinland-Pfalz 67657
    Germany

    Active - Recruiting

  • Dr. Murawski /ID# 272724

    Neunkirchen, Saarland 66538
    Germany

    Active - Recruiting

  • Medizinischen Versorgungszentrums Agilomed /ID# 274887

    Chemnitz, Sachsen 09130
    Germany

    Active - Recruiting

  • Dr. Mueller /ID# 273081

    Freiberg, Sachsen 09599
    Germany

    Active - Recruiting

  • Private Practice - Dr. Frank Hamann, Dr. Andreas Teich & Dr. Konrad Boche /ID# 275358

    Leipzig, Sachsen 04109
    Germany

    Active - Recruiting

  • Private Practice - Dr. Christine Baumann /ID# 275095

    Plauen, Sachsen 08523
    Germany

    Active - Recruiting

  • Praxis H. Fricke-Wagner /ID# 274467

    Zwickau, Sachsen 08056
    Germany

    Active - Recruiting

  • Rheumapraxis Dr. Liebhaber /ID# 274888

    Halle, Sachsen-Anhalt 06128
    Germany

    Active - Recruiting

  • Rheumatologische Facharztpraxis /ID# 272866

    Magdeburg, Sachsen-Anhalt 39104
    Germany

    Active - Recruiting

  • Private Practice - Dr. Thomas Kupka /ID# 273631

    Altenburg, Thueringen 04600
    Germany

    Active - Recruiting

  • Rheumazentrum Kupka /ID# 273631

    Altenburg, Thueringen 04600
    Germany

    Active - Recruiting

  • MVZ Herzogin Elisabeth Hospital /ID# 272725

    Brunswick, 38114
    Germany

    Active - Recruiting

  • Dres. Schuh /ID# 272731

    Coburg, 96450
    Germany

    Active - Recruiting

  • Praxis Dilltal /ID# 272727

    Ehringshausen, 35630
    Germany

    Active - Recruiting

  • Dr. Bestler /ID# 272741

    Erfurt, 99096
    Germany

    Active - Recruiting

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