Evaluation of Neuroprosthesis with Sensory Feedback for Modulation of Phantom Limb Pain and Enhancing Quality of Life

Inclusion Criteria:

• Amputation of the upper limb at the level of the forearm or upper arm, or amputationof the lower limb at the level of the lower leg or thigh.

• Age between 18 and 65 years.

• Duration since amputation is at least 6 months.

• Presence of persistent chronic pain syndrome rated between 4 and 10 on the VisualAnalog Scale (VAS).

• Absence of pregnancy at the time of implantation, confirmed by a pregnancy test (forfemale participants only).

• Signed consent to participate in the study.

Exclusion Criteria:

• Presence of severe somatic pathology that hinders surgical treatment andparticipation in the study.

• Presence of psychiatric disorders (including a history of), severe depression,suicidal tendencies, or a history of suicide attempts.

• Presence of severe orthopedic deformity in the limb above the level of amputation.

• History of cancer.

• History of epilepsy.

• Complicated traumatic brain injury (TBI) or a history of stroke.

• Inability to undergo electrostimulation due to other somatic pathology.

• Purulent-septic pathology.

• Drug addiction (including a history of).

• Congenital anomaly of upper limb development.

• Anomalies in the development of the central and peripheral nervous systems.