Cardiopulmonary Exercise Testing in Cardiosurgery Patients

Last updated: May 12, 2025
Sponsor: St. Anne's University Hospital Brno, Czech Republic
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Cardiopulmonary exercise testing

Clinical Study ID

NCT06702059
46/2024/OD
  • Ages > 18
  • All Genders

Study Summary

Cardiopulmonary exercise testing (CPET) is considered to be a gold standard in pre-operative risk assessment and stratification of high risk patients scheduled for major surgery. Surprisingly, only a limited number of studies examined the prognostic role of CPET in cardiothoracic surgery. This is in contrast with rather poor discriminating quality of cardiovascular surgery risk scores and predominantly elderly cardiovascular surgery patients, with significant comorbidity and high degree of frailty. Recently, CPET was shown feasible in coronary artery bypass grafting surgery candidates. Additionally, the rest parameter, which is the partial pressure of end-tidal carbon dioxide (PETCO2) and a submaximal exercise parameter (the VE/VCO2 slope) with good prognostic utility across multiple respiratory exchange ratio values), has been shown to predict mortality and post-operative complications.

Whether these rest and submaximal exercise parameters can be used to predict postoperative complications in cardiovascular surgery patients is yet to be determined.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patients scheduled for coronary artery bypass graft surgery

Exclusion

Exclusion Criteria:

  • not able to perform cardiopulmonary exercise testing, off-pump revascularization,without full sternotomy, previous cardiac surgery

Study Design

Total Participants: 130
Treatment Group(s): 1
Primary Treatment: Cardiopulmonary exercise testing
Phase:
Study Start date:
December 01, 2024
Estimated Completion Date:
April 01, 2028

Connect with a study center

  • Centre of Cardiovascular and Transplantation Surgery

    Brno, 60200
    Czech Republic

    Site Not Available

  • St. Anne's University Hospital in Brno

    Brno, 61200
    Czech Republic

    Site Not Available

  • Centre of Cardiovascular and Transplantation Surgery

    Brno, Czech Republic 60200
    Czechia

    Active - Recruiting

  • St. Anne's University Hospital in Brno

    Brno, Czech Republic 61200
    Czechia

    Site Not Available

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