Study of the Test-retest Reliability of the Neuropsychiatric Fluctuations Scale in Parkinson's Disease

Last updated: January 17, 2025
Sponsor: University Hospital, Grenoble
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Questionnaire and Physical Exam

Clinical Study ID

NCT06701955
38RC24.0196
2024-A01403-44
  • Ages 30-75
  • All Genders

Study Summary

This study focuses on neuropsychiatric fluctuations (NPF) in Parkinson's disease. Due to the lack of specific assessment tools, we developed the Neuropsychological Fluctuations Scale (NFS), a 20-item questionnaire. Recent studies have confirmed its reliability, sensitivity, and validity. To finalize its validation, assessing its test-retest reliability is an essential next step.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Age > 30 and ≤ 75 years

  • Idiopathic Parkinson's disease (according to the criteria of the Movement DisordersSociety)

  • Presence of motor fluctuations described by the patient, their relatives, oridentified by the clinician

  • Stability of antiparkinsonian treatment for at least one month

  • Mastery of the French language

  • Able to give consent.

  • Affiliated to the social security system

Exclusion

Exclusion Criteria:

Parkinsonian syndrome other than idiopathic Parkinson's disease

  • Dementia (MoCa < 23)

  • No antiparkinsonian treatment or treatment modified for less than one month

  • Persons referred to in Articles L1121-5 to L1121-8 of the CSP (corresponds to allprotected persons: pregnant women, parturients, breastfeeding mothers, personsdeprived of liberty by judicial or administrative decision, persons receivingpsychiatric care under Articles L. 3212-1 and L. 3213-1 who are not covered by theprovisions of Article L. 1121-8, persons admitted to a health or socialestablishment for purposes other than research, minors, persons subject to a legalprotection measure or unable to express their consent))

  • Subject in a period of exclusion from another interventional study.

Study Design

Total Participants: 100
Treatment Group(s): 1
Primary Treatment: Questionnaire and Physical Exam
Phase:
Study Start date:
February 01, 2025
Estimated Completion Date:
March 01, 2027

Study Description

During the progression of Parkinson's disease, a large number of patients experience fluctuations in motor status associated with neuropsychiatric fluctuations (NPF) (alternating episodes of depression, anxiety, and apathy with hypomanic states, impulsivity, and attention disorders). NPF may have a significant impact on patients' quality of life as well as on that of their caregivers. Moreover, the presence of these fluctuations is a risk factor for the development of self-medication behaviors, which can lead to addiction to antiparkinsonian treatments.

Due to the lack of specific tools for assessing NPF, our team developed a 20-item self-questionnaire specifically evaluating NPF in acute phases: the Neuropsychological Fluctuations Scale (NFS), which was first published in Movement Disorders, Clinical Practice (Schmitt et al., 2018). Recently, we studied the psychometric properties of the NFS in two populations of Parkinson's disease patients and in the general population (EFN Pre-Validation and EFN-Validation studies: ClinicalTrials.gov NCT04455074). The results regarding internal consistency, sensitivity, and specificity of the NFS, as well as its internal structure and external validity, were published in Frontiers in Neurology in 2023 (Schmitt et al., 2023). It has been demonstrated that the NFS is an innovative tool that complements existing motor and non-motor evaluations, and its utility in diagnosing and managing NPF is significant.

In order to finalize the validation of the NFS and further understand its psychometric characteristics, assessing the temporal stability of the NFS through test-retest reliability is an essential step.

Connect with a study center

  • CHUGA

    Grenoble,
    France

    Active - Recruiting

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