The Effect of Ketone Esters on Forearm Glucose Metabolism

Last updated: January 20, 2025
Sponsor: University of Exeter
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Placebo supplement

Ketone supplement

Clinical Study ID

NCT06685913
5390017
  • Ages 18-40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important tool for treating disease or recovering from exercise. The purpose of this research is to determine if a ketone drink can increase sugar uptake in our muscles. This research will provide new knowledge about the regulation of blood sugar.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18-40

Exclusion

Exclusion Criteria:

  • Any diagnosed metabolic health condition

  • Pregnant

  • Smoker

  • Diagnosed Cardiovascular disease

  • Use of medications deemed by research team to affect study outcomes

  • Recent history of musculoskeletal injury

  • Aged >40 or <18

  • Allergy to ingredients in the supplement, including ketones, lactose or milk protein

Study Design

Total Participants: 14
Treatment Group(s): 2
Primary Treatment: Placebo supplement
Phase:
Study Start date:
November 11, 2024
Estimated Completion Date:
December 31, 2034

Study Description

Impaired skeletal muscle glucose uptake following a meal ("insulin resistance"), is a primary risk factor for developing type 2 diabetes. We and others have consistently shown that ingesting exogenous ketones can reduce blood glucose concentration. Mechanistically, this must arise through reduced glucose release (i.e. from liver), and/or increased uptake (i.e. into skeletal muscle). Our current MRC-funded work is focussing on ketone-liver interactions in patients with type 2 diabetes. Here we aim to investigate how KE influence skeletal muscle glucose metabolism.

Connect with a study center

  • Nutritional Physiology Research Unit, University of Exeter

    Exeter, Devon EX1 2LU
    United Kingdom

    Active - Recruiting

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