Effect of Flozin (dapagliflozin) Administration on Myocardial and Peripheral Vascular Remodeling

Last updated: November 5, 2024
Sponsor: Poznan University of Medical Sciences
Overall Status: Active - Recruiting

Phase

N/A

Condition

Congestive Heart Failure

Chest Pain

Heart Failure

Treatment

N/A

Clinical Study ID

NCT06679179
199/23
  • Ages > 18
  • All Genders

Study Summary

The aim of this study is to assess the effect of treatment with flozin (dapagliflozin 10mg once a day) on haemodynamic parameters and myocardial and peripheral vascular remodeling in patients with NYHA class II-III heart failure.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • diagnosed heart failure NYHA class II and III

  • consent to participate in the study

  • patients should already be receiving treatment with an ACE inhibitor orsacubitril/valsartan or sartans, a beta-blocker, and an MRA, and should start onSGLT2i as part of therapy enhancement

Exclusion

Exclusion Criteria:

Study Design

Total Participants: 50
Study Start date:
March 10, 2023
Estimated Completion Date:
February 28, 2026

Study Description

In the available literature, there are reports of beneficial effects of flozins on improving myocardial systolic and diastolic function and isolated reports of effects on regression of organ damage (heart, vessels). These drugs significantly improve the prognosis of patients with heart failure, reduce total and cardiovascular mortality, reduce the number of exacerbations and the need for hospitalization, and have a beneficial effect on improving quality of life regardless of coexisting diabetes. New properties demonstrating the pleiotropic effect of the flozins are constantly being discovered. Drugs in this group are highly potent, selective and reversible inhibitors of the sodium ion-dependent glucose cotransporter 2 (SGLT2). The flozins have a low risk of side effects.

Connect with a study center

  • University Clinical Hospital in Poznań, 49 Przybyszewskiego Street, 60-355 Poznań

    Poznan, Wielkopolska 60-355
    Poland

    Active - Recruiting

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