FIH Trial of VERT-002 in Patients With Locally Advanced or Metastatic Solid Tumors With MET Alterations

Inclusion Criteria:

1. Part 1: histological confirmation of relapsed and/or refractory locally advanced ormetastatic solid tumor for which no standard of care treatment is available.

2. Part 2: histological confirmation of locally advanced or metastatic NSCLC StageIIIB/C or IV (American Joint Commission on Cancer [AJCC] 8th edition) inparticipants who are not eligible for or should have received available standard ofcare therapies including curative intent surgery, chemoradiation, radiotherapy orsystemic therapy.

3. Part 1: presence of at least one of the following MET alterations based on localdocumentation of blood or archived tissue results:

• METex14 mutation

• MET kinase domain activating gene mutations (e.g. H1094L/R/Y, D1228H/N/V,Y1230A/C/D/H)

• MET amplification

4. Part 2-a: presence of METex14 mutation (based on local documentation of blood orarchived tissue results) and for Part 2-b presence of at least one of the followingMET alterations: METex14 mutation (based on local documentation of blood or archivedtissue results), de novo MET amplification (based on local documentation of archivedtissue results). Confirmation after enrollment in the trial will be performed bycentral testing from an archival tumor biopsy sample (either tissue block or atleast 15 serial cut unstained slides of 5 μm, at least 20% tumor content). In caseno archival biopsy is available for central testing, the patient must be willing tohave a fresh tumor biopsy sample collected and the tumor biopsy should be deemedsafe and feasible by the investigator.

5. Part 2: at least one measurable target lesion according to RECIST v1.1.

6. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.

7. Part 1: participants may have received MET Tyrosine Kinase Inhibitor (TKI) as partof previous treatment, regardless of the line of therapy (first or second line), andregardless of the MET TKI being combined or not. Note: crizotinib will be considereda MET TKI.

8. Part 2: a maximum of 3 prior lines of systemic therapies.

9. Adequate hematologic function.

10. Adequate hepatic function.

11. Adequate renal function.

12. Albumin ≥ 3 g/dL.

13. Adequate coagulation function.

14. Adequate cardiac function.

15. Female participants of childbearing potential must have a negative highly sensitiveserum β-HCG test performed within 7 days prior to the first dose of VERT-002 and anegative urine pregnancy test performed at C1D1 prior to the first dose of VERT-002.

16. Male participants/partners with female spouse/partners of childbearing potentialmust agree to take appropriate precautions to avoid fathering a child.

NOTE: Other protocol defined inclusion criteria may apply.

Exclusion Criteria:

1. Part 2: Documented evidence by local testing of targetable oncogene drivermutations.

2. History of a primary malignancy other than the cancer under trial (as defined forParts 1 and 2) with the exception of:

• Participants with a previous malignancy who completed their anticancertreatment at least 2 years before signing informed consent and with no evidenceof residual disease from the prior malignancy at screening.

• Malignancies with a negligible risk of metastasis or death (i.e. 5-year overallsurvival rate > 90%) that are adequately treated.

3. Uncontrolled Central Nervous System (CNS) metastases or spinal cord compression thatare associated with progressive neurological symptoms or require increasing doses ofcorticosteroids to control the CNS disease.

4. History of hypersensitivity to active or inactive ingredients of VERT-002, or drugswith a similar chemical structure or from a similar class.

5. Active, bacterial, fungal, or viral infection, within 2 weeks prior to the firstdose of VERT-002 (C1D1).

6. Positive SARs-CoV-2 or variants of SARs-CoV2 test within 2 weeks prior to first doseadministration of VERT-002 (C1D1) or with suspected infection with SARs-CoV-2 orvariants of SARs-CoV-2 and confirmation pending.

7. Impaired cardiovascular function or clinically significant cardiovascular disease (either active or within 6 months prior to signing main informed consent).

8. Uncontrolled intercurrent illness including, but not limited to psychiatric illnessor social situation that would limit compliance with trial requirements.

9. Past medical history of Interstitial Lung Disease (ILD), drug induced ILD, radiationpneumonitis that requires steroid treatment, or any evidence of clinically activeILD.

10. Women who are pregnant or breastfeeding.

11. Prior anticancer therapy:

• MET TKI within 7 days prior to the first dose of VERT-002,

• Any other systemic anticancer therapy within 28 days or 5 half-lives of theanticancer therapy whichever is the shortest, but with a minimum of 14 daysinterval, prior to the first dose of VERT-002 (C1D1),

• Radiotherapy to a large field or including a vital organ (including whole brainradiotherapy or stereotactic radiosurgery to brain) within 14 days prior to thefirst dose of VERT-002 (C1D1).

12. Live attenuated vaccine within 28 days prior to the first dose of VERT-002 (C1D1).

13. Any toxicities from prior therapy with NCI- CTCAE Grade > 1 at the time of the firstdose administration of VERT-002 (C1D1). Exceptions include any grade alopecia,fatigue and peripheral neuropathy with a grade ≤ 2.

14. Major surgical procedure within 14 days of the first dose of VERT-002 (C1D1).

15. Participation in a clinical trial with administration of an investigational drugwithin 5 half- lives plus 14 days of the investigational drug, prior to the firstdose of VERT-002 (C1D1).

NOTE: Other protocol defined exclusion criteria may apply.