Chemical Debridement and Leg Ulcers

Inclusion Criteria:

• Participants with a venous leg ulcer or mixed aetiology ulcer.

• Duration of wound ≥ 6 weeks ≤ 5 years

• Wound is ≥ 5 cm2 ≤ 200cm2

• Presence of at least 25% visible slough within the wound bed

• The Participant must be able to understand the study and provide written informedconsent

• No clinical signs of infection

Exclusion Criteria:

• Known hypersensitivity or contraindications to any of the wound treatments,dressings or compression bandaging to be used in the trial

• Current local or systemic antibiotics in the week prior to inclusion

• Clinically infected wound as determined by the presence of 3 or more of thefollowing clinical signs: perilesional erythema, pain between two dressing changes,malodorous wound, abundant exudate and oedema

• Prolonged treatment with immunosuppressive agents or high dose corticosteroids

• Participants who have a current illness or condition which may interfere with woundhealing in the last 30 days (carcinoma, connective tissue disease, autoimmunedisease or alcohol or drug abuse)

• Participants who have participated in a clinical trial on wound healing within thepast month

• Participants with a known history of non- adherence with medical treatment