Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia

Last updated: February 24, 2026
Sponsor: Todd C. Lee MD MPH FIDSA
Overall Status: Active - Recruiting

Phase

4

Condition

Sepsis And Septicemia

Heart Disease

Soft Tissue Infections

Treatment

Daptomycin for Injection

Vancomycin (IV)

Clinical Study ID

NCT06637332
2025-10666
466322
  • Ages > 18
  • All Genders

Study Summary

This is an open label randomized controlled trial for patients with methicillin resistant S. aureus (MRSA) bloodstream infection which will directly compare the two most commonly used therapies, vancomycin and daptomycin.

This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119)

Eligibility Criteria

Inclusion

The participant must meet all inclusion and exclusion criteria for the SNAP Platform

Exclusion

(NCT05137119) and also the following inclusion and exclusion criteria:

Inclusion Criteria:

  • Methicillin-resistant S. aureus bacteremia

Exclusion Criteria:

  • Severe allergy or non-severe rash to vancomycin or daptomycin

  • Suspected or confirmed MRSA pneumonia

  • Known vancomycin minimum inhibitory concentration (MIC) greater than or equal to 2mg/L or daptomycin MIC greater than or equal to 1mg/L

Study Design

Total Participants: 300
Treatment Group(s): 2
Primary Treatment: Daptomycin for Injection
Phase: 4
Study Start date:
November 14, 2024
Estimated Completion Date:
November 30, 2027

Connect with a study center

  • Concord Repatriation and General Hospital

    Concord, New South Wales 2139
    Australia

    Site Not Available

  • John Hunter Hospital

    Newcastle, New South Wales 2305
    Australia

    Site Not Available

  • Westmead Hospital

    Westmead, New South Wales 2145
    Australia

    Site Not Available

  • Concord Repatriation and General Hospital

    Concord 2170852, New South Wales 2155400 2139
    Australia

    Active - Recruiting

  • John Hunter Hospital

    Newcastle 2155472, New South Wales 2155400 2305
    Australia

    Active - Recruiting

  • Westmead Hospital

    Westmead 2143973, New South Wales 2155400 2145
    Australia

    Active - Recruiting

  • Royal Brisbane and Women's Hospital

    Herston, Queensland 4029
    Australia

    Site Not Available

  • Royal Brisbane and Women's Hospital

    Herston 6931014, Queensland 2152274 4029
    Australia

    Active - Recruiting

  • Flinders Medical Centre

    Bedford Park, South Australia 5042
    Australia

    Site Not Available

  • Flinders Medical Centre

    Bedford Park 2076918, South Australia 2061327 5042
    Australia

    Active - Recruiting

  • Box Hill Hospital

    Box Hill, Victoria 3128
    Australia

    Site Not Available

  • Monash Medical Campus (Monash Medical Centre + Jesse McPherson Private Hospital)

    Clayton, Victoria 3168
    Australia

    Site Not Available

  • Royal Melbourne Hospital

    Parkville, Victoria 3050
    Australia

    Site Not Available

  • Box Hill Hospital

    Box Hill 2174360, Victoria 2145234 3128
    Australia

    Active - Recruiting

  • Monash Medical Campus (Monash Medical Centre + Jesse McPherson Private Hospital)

    Clayton 2171400, Victoria 2145234 3168
    Australia

    Active - Recruiting

  • Royal Melbourne Hospital

    Parkville 2153770, Victoria 2145234 3050
    Australia

    Active - Recruiting

  • Fiona Stanley Hospital

    Murdoch, Western Australia 6150
    Australia

    Site Not Available

  • Royal Perth Hospital

    Perth, Western Australia 6000
    Australia

    Site Not Available

  • Fiona Stanley Hospital

    Murdoch 8349091, Western Australia 2058645 6150
    Australia

    Active - Recruiting

  • Royal Perth Hospital

    Perth 2063523, Western Australia 2058645 6000
    Australia

    Active - Recruiting

  • Fraser Health Authority (Surrey Memorial Hospital)

    Surrey, British Columbia V3V1Z2
    Canada

    Site Not Available

  • Fraser Health Authority (Surrey Memorial Hospital)

    Surrey 6159905, British Columbia 5909050 V3V1Z2
    Canada

    Active - Recruiting

  • Newfoundland Health Services (Health Sciences Centre and St. Clare's Mercy Hospital)

    St. John's, Newfoundland and Labrador
    Canada

    Site Not Available

  • Newfoundland Health Services (Health Sciences Centre and St. Clare's Mercy Hospital)

    St. John's 6324733, Newfoundland and Labrador 6354959
    Canada

    Active - Recruiting

  • Hamilton Health Sciences (Hamilton General Hospital and Juravinski Hospital)

    Hamilton 5969782, Ontario 6093943 L8L 2X2
    Canada

    Active - Recruiting

  • McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)

    Montreal, Quebec H4A3S1
    Canada

    Site Not Available

  • McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)

    Montreal 6077243, Quebec 6115047 H4A3S1
    Canada

    Active - Recruiting

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