Evaluating Gardasil HPV Vaccine Humoral and Cellular Immune Responses in People With and Without HIV

Inclusion Criteria:

• 18 years old or older and 70 years old or younger

• Able to provide informed consent

• Denies history of prior HPV vaccination with Gardasil9 (receipt of HPV vaccinationother than Gardasil9 such as the bivalent or the quadrivalent HPV vaccine will beallowed) or unsure of vaccination status and born before 2003

• Born Male

For Test group: HIV-positive people born male with current or past exposure to androgen blockers or estrogen (BM-EABE)

• Living with HIV

• Current or past exposure to androgen blockers or estradiol

For Control group: HIV-negative Control

• HIV negative

• Either: Current or past exposure to androgen blockers or estradiol; no current orpast exposure to androgen blockers or estradiol AND had sex with a person with apenis in the last year

Exclusion Criteria:

• Younger than 18 years old or older than 70 years old.

• Self-reported or documented history of nine-valent HPV vaccine or unsure ofvaccination status and born after 2003.

• Born female

• History of hypersensitivity, including severe reactions to yeast or other componentof the vaccine.

• Any condition requiring systemic chemotherapy or immunomodulant affecting antibodyresponses (i.e., rituximab, ibrutinib etc.), intravenous or subcutaneousimmunoglobulin supplementation, radiation therapy, or immunomodulatory treatmentwithin the previous 6 months (presence of precancerous lesions is not exclusionary).