Use of Sodium Bicarbonate As Prophylaxis for Kidney Damage in Patients with Heatstroke

Last updated: September 30, 2024
Sponsor: Hospital General de Mexicali
Overall Status: Active - Recruiting

Phase

N/A

Condition

Kidney Disease

Low Blood Pressure (Hypotension)

Renal Failure

Treatment

Sodium bicarbonate

No intervention

Clinical Study ID

NCT06622525
HGMexicali
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study protocol aims to prevent the need for renal replacement therapy in patients with rhabdomyolysis secondary to heatstroke. It is based on previous studies showing that bicarbonate infusion reduces renal failure in similar contexts. The intervention will be conducted at the General Hospital of Mexicali during the summer, targeting the prevention of renal failure and reducing the necessity for renal replacement therapy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Admitted to the General Hospital of Mexicali with the diagnosis of heat stroke.

  • Meeting the operational definition (exposure to heat, body temperature at admissiongreater than 40 degrees Celsius).

  • CPK level greater than 1000 U/L.

  • Having informed consent from the patient or the legally responsible adult.

Exclusion

Exclusion Criteria:

  • Exclusion of the heat stroke diagnosis during their evaluation.

  • Lack of serum creatinine levels at the time of admission to the protocol.

Study Design

Total Participants: 1
Treatment Group(s): 2
Primary Treatment: Sodium bicarbonate
Phase:
Study Start date:
May 01, 2024
Estimated Completion Date:
October 01, 2025

Study Description

The present study protocol explores the possibility of preventing the need for renal replacement therapy in patients who develop rhabdomyolysis secondary to heatstroke. This is based on previous studies that have used bicarbonate infusion in the context of rhabdomyolysis secondary to compartment syndrome, finding a lower incidence of renal failure. Due to the aforementioned, we propose to carry out a similar intervention at the General Hospital of Mexicali, where there is a significant incidence of heatstroke during the summer months. The aim is to determine whether this intervention is useful in preventing the development of renal failure and the requirement for renal replacement therapy.

Connect with a study center

  • Hospital General de Mexicali

    Mexicali, Baja California 21000
    Mexico

    Active - Recruiting

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