Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease

Last updated: January 13, 2025
Sponsor: CND Life Sciences
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sleep Disorders

Treatment

N/A

Clinical Study ID

NCT06621602
MJFF-025208
  • Ages 50-100
  • All Genders

Study Summary

This study aims to assess the levels of phosphorylated alpha-synuclein (P-SYN) in patients with Parkinson's disease and REM Behavior Disorder using a minimally invasive skin punch biopsy. It seeks to understand the natural progression of P-SYN deposition over time to explore the potential of P-SYN quantification as a biomarker for disease progression.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Male and female 50 to 100 years of age

  2. Clinical confirmed diagnosis of Parkinson's disease or REM Sleep Behavior

Exclusion

Exclusion Criteria:

  1. Clinical evidence of severe vascular disease (history of ulceration, poor woundhealing or vascular claudication)

  2. History of allergic reaction to Lidocaine for local anesthesia needed for skinbiopsies

  3. Use of blood thinners (Plavix or Aspirin used separately is allowed)

  4. Significantly impaired wound healing or history of scarring or keloid formation

Study Design

Total Participants: 100
Study Start date:
December 17, 2024
Estimated Completion Date:
April 30, 2026

Study Description

This is a prospective, longitudinal study involving 75 Parkinson's disease patients and 25 patients with REM Behavior Disorder. Each participant will undergo a baseline evaluation followed by follow-ups every six months over an 18-month period. The evaluations will include clinical assessments, neurologic exams, and skin biopsies from three locations. Data will be collected on disease progression and the amount of P-SYN in cutaneous nerve fibers.

Connect with a study center

  • CND Life Sciences

    Scottsdale, Arizona 85258
    United States

    Active - Recruiting

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