A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

Last updated: May 19, 2025
Sponsor: Bristol-Myers Squibb
Overall Status: Active - Recruiting

Phase

1/2

Condition

Non-small Cell Lung Cancer

Lung Cancer

Cancer

Treatment

Pembrolizumab

BMS-986507

Osimertinib

Clinical Study ID

NCT06618287
CA244-0001
2024-514947-27
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.

Eligibility Criteria

Inclusion

Inclusion Criteria

  • Participants must have at least one measurable lesion per response evaluation criteria in solid tumors.

  • Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1.

  • Participants must have a life expectancy of at least 3 months at the time of the first dose.

Exclusion Criteria

  • Participants must not have any mixed Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC) histology.

  • Participants must not have any untreated symptomatic central nervous system (CNS) metastases.

  • Participants must not have a history of serious recurrent infections.

  • Participants must not have a history of severe heart disease.

  • Other protocol-defined Inclusion/Exclusion criteria apply.

Study Design

Total Participants: 218
Treatment Group(s): 3
Primary Treatment: Pembrolizumab
Phase: 1/2
Study Start date:
February 04, 2025
Estimated Completion Date:
December 23, 2027

Connect with a study center

  • Liverpool Hospital

    Liverpool, New South Wales 2170
    Australia

    Active - Recruiting

  • Local Institution - 0027

    Liverpool, New South Wales 2170
    Australia

    Site Not Available

  • Local Institution - 0028

    Woolloongabba, Queensland 4102
    Australia

    Site Not Available

  • Princess Alexandra Hospital

    Woolloongabba, Queensland 4102
    Australia

    Active - Recruiting

  • Local Institution - 0024

    Edmonton, Alberta T6G 1Z2
    Canada

    Site Not Available

  • Local Institution - 0064

    Newmarket, Ontario L3Y 2P9
    Canada

    Site Not Available

  • Local Institution - 0023

    Ottawa, Ontario K1H 8L6
    Canada

    Site Not Available

  • Local Institution - 0026

    Ottawa, Ontario K1H 8L6
    Canada

    Site Not Available

  • The Ottawa Hospital - General Campus

    Ottawa, Ontario K1H 8L6
    Canada

    Active - Recruiting

  • Jewish General Hospital

    Montreal, Quebec H3T 1E2
    Canada

    Active - Recruiting

  • Local Institution - 0025

    Montreal, Quebec H3T 1E2
    Canada

    Site Not Available

  • Centre Hospitalier de l'Université de Montréal

    Montréal, Quebec H2X 3E4
    Canada

    Active - Recruiting

  • Local Institution - 0022

    Montréal, Quebec H2X 0A9
    Canada

    Site Not Available

  • Local Institution - 0047

    Santiago, Región Metropolitana De Santiago 8420383
    Chile

    Site Not Available

  • Local Institution - 0048

    Santiago, Región Metropolitana De Santiago 7500921
    Chile

    Site Not Available

  • Local Institution - 0049

    Santiago, Región Metropolitana De Santiago 7620002
    Chile

    Site Not Available

  • Local Institution - 0043

    Bordeaux, Aquitaine 33076
    France

    Site Not Available

  • Local Institution - 0045

    Marseille, Bouches-du-Rhône 13385
    France

    Site Not Available

  • Local Institution - 0053

    Montpellier, Hérault 34090
    France

    Site Not Available

  • Local Institution - 0050

    Lyon, Rhône-Alpes 69008
    France

    Site Not Available

  • Local Institution - 0041

    Villejuif, Val-de-Marne 94800
    France

    Site Not Available

  • Local Institution - 0040

    Paris, 75970
    France

    Site Not Available

  • Local Institution - 0054

    Paris, 75248
    France

    Site Not Available

  • Local Institution - 0034

    Aviano, Friuli-Venezia Giulia 33081
    Italy

    Site Not Available

  • Local Institution - 0033

    Milan, Lombardia 20133
    Italy

    Site Not Available

  • Local Institution - 0056

    Candiolo, Torino 10060
    Italy

    Site Not Available

  • Local Institution - 0035

    Firenze, Toscana 50134
    Italy

    Site Not Available

  • Local Institution - 0032

    Roma, 00168
    Italy

    Site Not Available

  • Local Institution - 0004

    Leiden, Zuid-Holland 2333 ZA
    Netherlands

    Site Not Available

  • Local Institution - 0003

    Amsterdam, 1066 CX
    Netherlands

    Site Not Available

  • Local Institution - 0062

    Santiago de Compostela, A Coruña [La Coruña] 15706
    Spain

    Site Not Available

  • Local Institution - 0016

    Barcelona, Barcelona [Barcelona] 08035
    Spain

    Site Not Available

  • Local Institution - 0058

    Hospitalet, Barcelona [Barcelona] 08907
    Spain

    Site Not Available

  • Local Institution - 0059

    Barcelona, Catalunya [Cataluña] 08036
    Spain

    Site Not Available

  • Local Institution - 0018

    Madrid, Madrid, Comunidad De 28041
    Spain

    Site Not Available

  • Local Institution - 0061

    Majadahonda, Madrid, Comunidad De 28222
    Spain

    Site Not Available

  • Local Institution - 0017

    Madrid, 28040
    Spain

    Site Not Available

  • Local Institution - 0019

    Madrid, 28050
    Spain

    Site Not Available

  • Local Institution - 0063

    Málaga, 29011
    Spain

    Site Not Available

  • Local Institution - 0060

    València, 46026
    Spain

    Site Not Available

  • Local Institution - 0020

    Birmingham, England B15 2TH
    United Kingdom

    Site Not Available

  • Local Institution - 0030

    London, England NW32QG
    United Kingdom

    Site Not Available

  • Local Institution - 0021

    Glasgow, Glasgow City G12 0YN
    United Kingdom

    Site Not Available

  • Local Institution - 0001

    Newcastle upon Tyne, NE7 7DN
    United Kingdom

    Site Not Available

  • Local Institution - 0066

    Birmingham, Alabama 35294-3300
    United States

    Site Not Available

  • Local Institution - 0009

    Miami, Florida 33136
    United States

    Site Not Available

  • Local Institution - 0065

    Iowa City, Iowa 52242
    United States

    Site Not Available

  • John Theurer Cancer Center at Hackensack University Medical Center

    Hackensack, New Jersey 07601
    United States

    Active - Recruiting

  • Local Institution - 0010

    Hackensack, New Jersey 07601
    United States

    Site Not Available

  • Cleveland Clinic

    Cleveland, Ohio 44195
    United States

    Active - Recruiting

  • Local Institution - 0029

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • Local Institution - 0052

    Portland, Oregon 97239
    United States

    Site Not Available

  • Local Institution - 0014

    Pittsburgh, Pennsylvania 15232
    United States

    Site Not Available

  • Local Institution - 0012

    Seattle, Washington 98104
    United States

    Site Not Available

  • Swedish Medical Center

    Seattle, Washington 98104
    United States

    Active - Recruiting

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