A Study Evaluating the Safety, Tolerability, and Efficacy of EVO756 in Adults With Chronic Inducible Urticaria

Last updated: April 11, 2025
Sponsor: Evommune, Inc.
Overall Status: Active - Not Recruiting

Phase

2

Condition

Urticaria

Treatment

Oral EVO756

Clinical Study ID

NCT06603220
EVO756-CIU001
  • Ages 18-65
  • All Genders

Study Summary

This phase 2a trial will evaluate the safety and efficacy of EVO756 in subjects with chronic inducible urticaria, including symptomatic dermographism and cold urticaria.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Confirmed diagnosis of chronic inducible urticaria for at least 3 months.

  • Positive response following provocation using the TempTest or FricTest at Screeningand Day 1.

Exclusion

Exclusion Criteria:

  • History of diseases other than chronic inducible urticaria or chronic spontaneousurticaria with urticaria or angioedema symptoms, such as urticarial vasculitis,erythema multiforme, cutaneous mastocytosis (urticaria pigmentosa), and hereditaryor acquired angioedema.

  • Concurrent use of certain medications, including antihistamines.

  • Any clinically significant disease, or other skin disease or skin markings (e.g.,extensive scarring, tattoos), that might confound the evaluation of safety orefficacy.

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Oral EVO756
Phase: 2
Study Start date:
August 14, 2024
Estimated Completion Date:
May 31, 2025

Connect with a study center

  • AllerVie Clinical Research

    Birmingham, Alabama 35209
    United States

    Active - Recruiting

  • Cahaba Dermatology & Skin Health Center, LLC

    Birmingham, Alabama 35244
    United States

    Site Not Available

  • California Allergy and Asthma Medical Group

    Los Angeles, California 90025
    United States

    Site Not Available

  • Integrative Skin Science and Research

    Sacramento, California 95815
    United States

    Site Not Available

  • West Dermatology Research Center

    San Diego, California 92121
    United States

    Site Not Available

  • Advanced Clinical Research Institute

    Tampa, Florida 33607
    United States

    Site Not Available

  • The Allergy Center at Brookstone

    Columbus, Georgia 31904
    United States

    Site Not Available

  • Aeroallergy Research Laboratories of Savannah, Inc.

    Savannah, Georgia 31406
    United States

    Site Not Available

  • Treasure Valley Medical Research

    Boise, Idaho 83706
    United States

    Site Not Available

  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana 46250
    United States

    Site Not Available

  • Southern Indiana Clinical Trials

    New Albany, Indiana 47150
    United States

    Site Not Available

  • Indiana Clinical Trials Center, P.C.

    Plainfield, Indiana 46168
    United States

    Site Not Available

  • DelRicht Research

    Baton Rouge, Louisiana 70809
    United States

    Site Not Available

  • Chesapeake Clinical Research, Inc

    White Marsh, Maryland 21162
    United States

    Site Not Available

  • OptiSkin Medical

    New York, New York 10128
    United States

    Site Not Available

  • Red River Research Partners

    Fargo, North Dakota 58013
    United States

    Site Not Available

  • Bexley Dermatology Research

    Bexley, Ohio 43209
    United States

    Site Not Available

  • Allergy, Asthma, and Clinical Research Center

    Oklahoma City, Oklahoma 73120
    United States

    Site Not Available

  • Allergy and Clinical Immunology Associates

    Pittsburgh, Pennsylvania 15241
    United States

    Site Not Available

  • Austin Institute for Clinical Research

    Pflugerville, Texas 78660
    United States

    Site Not Available

  • STAAMP Research LLC

    San Antonio, Texas 78229
    United States

    Site Not Available

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