Phase
Condition
Warts
Psoriasis And Psoriatic Disorders
Rosacea
Treatment
Apremilast
Placebo
ESK-001
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Males or females, age ≥18 years
Diagnosis of plaque psoriasis for ≥6 months
Plaques covering ≥10% of BSA
PASI ≥12
sPGA ≥3
Women of childbearing potential (WOCBP) and males who are sexually active with WOCBPmust agree to adhere to highly effective methods of contraception
Exclusion
Exclusion Criteria:
Nonplaque psoriasis or other inflammatory skin conditions
immune-mediated conditions commonly associated with psoriasis (eg inflammatory boweldisease). Participants with psoriatic arthritis may participate
Pregnant, lactating, or planning to get pregnant during the study
Use of drugs prior to Study Day 1 that treat or may affect psoriasis:
Topical within 2 weeks
Phototherapy or any systemic treatments within 4 weeks
Any biologic agent targeted to IL-12 or IL-23 within 6 months, oral IL-12 orIL-23 or TNFα inhibitor within 2 months, or IL-17 within 4 months
Systemic immunosuppressants or immunomodulatory drugs within 4 weeks
Modulators of B cells within 6 months, or T cells within 3 months
JAK inhibitors or TYK2 inhibitors within 4 weeks
PDE4 inhibitor within 2 months
Any investigational agent, within 30 days or 5 half-lives or is currentlyenrolled in an investigational study
Lack of clinical response to a TYK2, IL-12, or IL-23 targeted psoriasis treatment
Participants with QTcF >450 msec (males) or >470 msec (females) at Screening
Unstable cardiovascular disease, defined as a recent clinical deterioration or acardiac hospitalization within the last 3 months
Evidence of recent or recurrent herpes zoster or herpes simplex viral infection
Evidence of active infection or positive test result for hepatitis B, hepatitis C,HIV or TB
History of serious bacterial, fungal, or viral infections that led tohospitalization, or any recent serious infection requiring antibiotic treatment
Any history of known or suspected congenital or acquired immunodeficiency state orcondition that would compromise the participant's immune status
Lab abnormalities indicating significant renal, hepatic or bone marrow dysfunction
History of any immune-mediated or inflammatory medical condition for whichparticipants requires current systemic corticosteroids
- Stable doses of inhaled corticosteroids for treatment of asthma are allowed
Known current malignancy or current evaluation for a potential malignancy or historyof malignancy within the past 5 years prior to screening, except for adequatelytreated basal cell or squamous cell skin carcinoma or carcinoma in situ of thecervix
Live vaccines within 4 weeks prior to Study Day 1
Participant has planned surgery during the study period
Any acute or chronic illness/condition or evidence of an unstable clinical conditionthat, in the opinion of the Investigator, will substantially increase the risk tothe participant if he or she participates in the study
History of mental illness within the last 5 years, unless receiving a fixed regimenof psychiatric medications for at least 6 months before screening or has notrequired or been prescribed any psychiatric medication within 12 months beforescreening
Evidence of severe depressive symptoms or active suicidal ideation or behavior
Study Design
Connect with a study center
Premier Specialists
Kogarah, New South Wales 2217
AustraliaSite Not Available
Westmead Hospital
Westmead, New South Wales 2145
AustraliaSite Not Available
Veracity Clinical Research
Woolloongabba, Queensland 4102
AustraliaSite Not Available
North Eastern Health Specialists (NEHS)
Campbelltown, South Australia 5074
AustraliaSite Not Available
Skin Health Institute Inc.
Carlton, Victoria 3053
AustraliaSite Not Available
Sinclair Dermatology
East Melbourne, Victoria 3002
AustraliaSite Not Available
C H U de Liege
Liège, Liege 4000
BelgiumSite Not Available
Multiprofile Hospital for Active Treatment Dr Tota Venkova
Gabrovo, 5300
BulgariaSite Not Available
Medikal Center Kordis
Pleven, 5800
BulgariaSite Not Available
Diagnostic Consultative Center Aleksandrovska EOOD
Sofia, 1431
BulgariaSite Not Available
Skin and Venereal Diseases Center EOOD
Sofia, 1404
BulgariaSite Not Available
University Multiprofile Hospital for Active Treatment Alexandrovska
Sofia, 1431
BulgariaSite Not Available
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna ISUL EAD
Sofia, 1527
BulgariaSite Not Available
Clineca
Stara Zagora, 6000
BulgariaSite Not Available
Rejuvenation Medical Group Edmonton Downtown
Edmonton, Alberta T5J 3S9
CanadaSite Not Available
Enverus Medical Research
Surrey, British Columbia V3V 0C6
CanadaSite Not Available
Dermatrials Research Inc.
Hamilton, Ontario L8N 1Y2
CanadaSite Not Available
Centricity Research
London, Ontario N6A 2C2
CanadaSite Not Available
DermEffects
London, Ontario N6H 5L5
CanadaSite Not Available
Lynderm Research Inc.
Markham, Ontario L3P 1X3
CanadaSite Not Available
DermEdge Research
Mississauga, Ontario L4Y 4C5
CanadaSite Not Available
Institute of Cosmetic & Laser Surgery
Oakville, Ontario L6J 7W5
CanadaSite Not Available
The Centre for Dermatology
Richmond Hill, Ontario L4B 1A5
CanadaSite Not Available
Canadian Dermatology Centre
Toronto, Ontario M3B 0A7
CanadaSite Not Available
Dermatology on Bloor
Toronto, Ontario M4W 2N4
CanadaSite Not Available
North York Research Inc.
Toronto, Ontario M2N3A6
CanadaSite Not Available
Alliance Clinical Trials
Waterloo, Ontario N2J 1C4
CanadaSite Not Available
"Centre de Recherche Dermatologique du Quebec Metropolitain Inc."
Québec, Quebec G1V 4X7
CanadaSite Not Available
Dermatologie Sima Inc.
Verdun, Quebec H4G 3E7
CanadaSite Not Available
Pratia Brno s.r.o.
Brno, Moravia 60200
Czech RepublicActive - Recruiting
Dermskin, s.r.o.
Olomouc, Moravia 77900
Czech RepublicActive - Recruiting
Kozni ambulance Kutna Hora, s.r.o.
Kutna Hora, 28401
Czech RepublicActive - Recruiting
DERMAMEDICA, s.r.o.
Nachod, 54701
Czech RepublicActive - Recruiting
Nemocnice Nový Jičín, A.S.
Nový Jičín, 74101
Czech RepublicActive - Recruiting
CCR Ostrava, s.r.o.
Ostrava, 70200
Czech RepublicActive - Recruiting
Vesalion sro
Ostrava, 70200
Czech RepublicActive - Recruiting
Pratia Pardubice a.s.
Pardubice, 53002
Czech RepublicActive - Recruiting
Clintrial s.r.o.
Prague, 100 00
Czech RepublicActive - Recruiting
Praglandia
Prague, 15000
Czech RepublicActive - Recruiting
Pratia Prague, s.r.o.
Prague, 13000
Czech RepublicActive - Recruiting
Sanatorium Profesora Arenbergera
Prague, 110 00
Czech RepublicActive - Recruiting
Dermatologicka ambulance - Svitavy
Svitavy, 568 02
Czech RepublicActive - Recruiting
MUDr Radka Neumannova
Svitavy, 56802
Czech RepublicActive - Recruiting
Fakultni nemocnice Plzen Dermatovenerologicka klinika
Plzen, Bory 301 00
CzechiaSite Not Available
Pratia Brno s.r.o.
Brno, Moravia 60200
CzechiaSite Not Available
Dermskin, s.r.o.
Olomouc, Moravia 77900
CzechiaSite Not Available
Kozni ambulance Kutna Hora, s.r.o.
Kutna Hora, 28401
CzechiaSite Not Available
DERMAMEDICA, s.r.o.
Nachod, 54701
CzechiaSite Not Available
Nemocnice Nový Jičín, A.S.
Nový Jičín, 74101
CzechiaSite Not Available
CCR Ostrava, s.r.o.
Ostrava, 70200
CzechiaSite Not Available
Vesalion sro
Ostrava, 70200
CzechiaSite Not Available
Pratia Pardubice a.s.
Pardubice, 53002
CzechiaSite Not Available
Clintrial s.r.o.
Prague, 100 00
CzechiaSite Not Available
Fakultni Nemocnice Kralovske Vinohrady FNKV Dermatovenerologicka Klinika
Prague, 10034
CzechiaSite Not Available
Praglandia
Prague, 15000
CzechiaSite Not Available
Pratia Prague, s.r.o.
Prague, 13000
CzechiaSite Not Available
Sanatorium Profesora Arenbergera
Prague, 110 00
CzechiaSite Not Available
Dermatologicka ambulance - Svitavy
Svitavy, 568 02
CzechiaSite Not Available
MUDr Radka Neumannova
Svitavy, 56802
CzechiaSite Not Available
Eberhard Karls Universitaet Tuebingen Universitaets Hautklinik Tuebingen
Tuebingen, Baden-Württemberg 72070
GermanySite Not Available
Hautarztpraxis Dr. Mihaescu
Augsburg, Bayern 86150
GermanySite Not Available
emovis GmbH
Berlin, Brandenburg 10629
GermanySite Not Available
Hautarztpraxis Mahlow
Mahlow, Brandenburg 15831
GermanySite Not Available
Klinikum Darmstadt GmbH - Hautklinik
Darmstadt, Hessen 64283
GermanySite Not Available
Universitatsklinikum Frankfurt
Frankfurt, Hessen 60590
GermanySite Not Available
Fachklinik Bad Bentheim
Bad Bentheim, Lower Saxony 48455
GermanySite Not Available
Hautarztpraxis an der Hase
Bramsche, Lower Saxony 49565
GermanySite Not Available
Siteworks
Lohne, Lower Saxony 49393
GermanySite Not Available
Klinikum Bielefeld
Bielefeld, NRW 33647
GermanySite Not Available
Universitatsklinikum Bonn
Bonn, NRW 53127
GermanySite Not Available
Pro Derma
Dülmen, NRW 48249
GermanySite Not Available
Intramedis CSS
Remscheid, NRW 42897
GermanySite Not Available
Universitätsklinikum Köln
Cologne, North Rhine-Westphalia 50937
GermanySite Not Available
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz Clinical Research Center CRC
Mainz, Rhineland-Palatinate 55131
GermanySite Not Available
Universitatsklinikum Carl Gustav Carus an der Technischen Universitat Dresden
Dresden, Saxonia 1307
GermanySite Not Available
Universitatsklinikum Schleswig-Holstein
Kiel, Schleswig-Holstein 24105
GermanySite Not Available
Charite Universitaetsmedizin Berlin Campus Virchow Klinikum CVK
Berlin, 10117
GermanySite Not Available
Fukuoka University Hospital
Fukuoka, Fukuoka-shi 814-0180
JapanSite Not Available
Asahikawa Medical University Hospital
Asahikawa, Hokkaido 078-8510
JapanSite Not Available
Nihon University Itabashi Hospital
Tokyo, Itabashi-Ku 173-8610
JapanSite Not Available
Saruwatari Dermatology Clinic
Kagoshima, Kagoshima-Shi 890-0046
JapanSite Not Available
Kanto Rosai Hospital
Kanagawa, Kawasaki-shi 211-8510
JapanSite Not Available
Yamanashi Prefectural Central Hospital
Yamanashi, Kofu-shi 400-8506
JapanSite Not Available
Nagoya City University Hospital
Aichi, Nagoya-shi 467-8602
JapanSite Not Available
Okayama University Hospital
Okayama, Okayama-shi 700-8558
JapanSite Not Available
Nippon Life Hospital
Osaka, Osaka-Shi 550-0006
JapanSite Not Available
Osaka Metropolitan University Hospital
Osaka, Osaka-shi 545-8586
JapanSite Not Available
National Hospital Organization Sagamihara National Hospital
Kanagawa, Sagamihara 252-0392
JapanSite Not Available
National Hospital Organization Sagamihara National Hospital
Kanagawa-Ken, Sagamihara 252-0392
JapanSite Not Available
Dermatology and Ophthalmology Kume Clinic
Osaka, Saka-Shi 593-8324
JapanSite Not Available
Hokkaido University Hospital
Hokkaido, Sapporo-shi 060-8648
JapanSite Not Available
Kindai University Hospital
Osaka, Sayama-Shi 589-8511
JapanSite Not Available
Tohoku University Hospital
Miyagi, Sendai-Shi 980-0872
JapanSite Not Available
Tokyo Medical University Hospital
Tokyo, Shinjuku-Ku 160-0023
JapanSite Not Available
Osaka University Hospital
Osaka, Suita-shi 565-0871
JapanSite Not Available
Medical Corporation Jitai kai Tachikawa Dermatology Clinic
Tokyo, Tachikawa-shi 190-0023
JapanSite Not Available
Mie University Hospital
Mie, Tsu-shi 514-8507
JapanSite Not Available
Yamaguchi University Hospital
Yamaguchi, Ube-shi 755-8505
JapanSite Not Available
Yokohama City University Hospital
Kanagawa, Yokohama-shi 236-0004
JapanSite Not Available
Chosun Universtiy Hospital
Gwangju, Dong-gu 61453
Korea, Republic ofSite Not Available
Konkuk University Medical Center
Seoul, Gwangjin-gu 05030
Korea, Republic ofSite Not Available
Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggi-do 14068
Korea, Republic ofSite Not Available
CHA Bundang Medical Center
Seongnam-si, Gyeonggi-do 13496
Korea, Republic ofSite Not Available
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do 13620
Korea, Republic ofSite Not Available
Konkuk University Medical Center
Gwangjin-gu, Seoul 05030
Korea, Republic ofSite Not Available
Asan Medical Center
Seoul, Songpa-gu 05505
Korea, Republic ofSite Not Available
Pusan National University Hospital
Busan, 49241
Korea, Republic ofSite Not Available
Kyung Hee University Medical Center
Seoul, 02447
Korea, Republic ofSite Not Available
Seoul National University Hospital
Seoul, 03080
Korea, Republic ofSite Not Available
Seoul St Marys Hospital
Seoul, 06591
Korea, Republic ofSite Not Available
Centrum Medyczne Synexus Wroclaw
Wroclaw, Dolnoslaskie 50-381
PolandSite Not Available
Centrum Medyczne Pratia Bydgoszcz
Bydgoszcz, Kujawsko-Pomorskie 85796
PolandSite Not Available
Velocity Clinical Research, Skierniewice
Skierniewice, Lodzkie 96-100
PolandSite Not Available
WroMedica
Wroclaw, Lower Silesia 51-685
PolandSite Not Available
Specjalistyczny Ośrodek Alergologiczno-Internistyczny "ALL-MED"
Krakow, MA 30-033
PolandSite Not Available
Diamond Clinic
Krakow, Malopolska 31-559
PolandSite Not Available
Centrum Medyczne Reuma Park
Warsaw, Mazovia 02-665
PolandSite Not Available
FutureMeds Warszawa Centrum
Warsaw, Mazovia 00215
PolandSite Not Available
High Med Przychodnia Specjalistyczna
Warsaw, Mazovia 01-817
PolandSite Not Available
MICS Medical Center Warsaw
Warsaw, Mazovia 00-874
PolandSite Not Available
RoyalDerm
Warsaw, Mazowiecke 02-962
PolandSite Not Available
ClinicMed Daniluk, Nowak Spolka Komandytowa
Bialystok, Podlaskie 15-879
PolandSite Not Available
AES Gdansk
Gdansk, Pomorskie 80-382
PolandSite Not Available
Centrum Medyczne Synexus Gdynia
Gdynia, Pomorskie 81-537
PolandSite Not Available
Derm Art Institute
Gdynia, Pomorskie 81-415
PolandSite Not Available
Centrum Medyczne Angelius Provita (Angelius Provita Medical Centre)
Katowice, Silesia 40-611
PolandSite Not Available
Laser Clinic
Szczecin, Zachodniopomorskie 70-332
PolandSite Not Available
Centrum Badań Klinicznych PI House Sp. Z O.O.
Gdańsk, 80-546
PolandSite Not Available
Pratia Małopolskie Centrum Medyczne (MCM) Kraków
Krakow, 30-727
PolandSite Not Available
Centrum Medyczne Synexus Warszawa
Warsaw, 02-672
PolandSite Not Available
Rheuma Medicus
Warsaw, 02-118
PolandSite Not Available
Hospital da Senhora da Oliveira
Guimaraes, Braga 4835-044
PortugalSite Not Available
Unidade Local de Saude Braga
Braga, 4710-243
PortugalSite Not Available
Hospital CUF Descobertas
Lisbon, 1998-018
PortugalSite Not Available
Unidade Local de Saude Santo Antonio Hospital de Santo Antonio
Porto, 4099-001
PortugalSite Not Available
Alliance Dermatology
Phoenix, Arizona 85032
United StatesSite Not Available
Scottsdale Clinical Trials
Scottsdale, Arizona 85260
United StatesSite Not Available
Northwest Arkansas Clinical Trials Center (NWACTC), PLLC
Rogers, Arkansas 72758-8600
United StatesSite Not Available
Exalt Clinical Research
Chula Vista, California 91910
United StatesSite Not Available
California Dermatology & Clinical Research Institute
Encinitas, California 92024-7700
United StatesSite Not Available
First OC Dermatology Research Inc
Fountain Valley, California 92708
United StatesSite Not Available
Marvel Clinical Research, LLC
Huntington Beach, California 92647
United StatesSite Not Available
Sunwise Clinical Research, LLC
Lafayette, California 94549
United StatesSite Not Available
Wallace Medical Group Inc
Los Angeles, California 90056
United StatesSite Not Available
Northridge Clinical Trials - Elite Clinical Network
Northridge, California 91325
United StatesSite Not Available
Pasadena Clinical Trials
Pasadena, California 91101
United StatesSite Not Available
Therapeutics Clinical Research
San Diego, California 92123
United StatesSite Not Available
Unison Clinical Trials/ Shahram Jacobs MD
Sherman Oaks, California 91403-1814
United StatesSite Not Available
Olive View - UCLA Education & Research Institute
Sylmar, California 91342
United StatesSite Not Available
California Dermatology Institute - Thousand Oaks
Thousand Oaks, California 91320-2130
United StatesSite Not Available
Clearlyderm Dermatology - West Boca Raton
Boca Raton, Florida 33428
United StatesSite Not Available
Driven Clinical Research
Coral Gables, Florida 33134
United StatesSite Not Available
Jacksonville Center for Clinical Research
Jacksonville, Florida 32216
United StatesSite Not Available
Accel Research Sites - Maitland
Maitland, Florida 32751
United StatesSite Not Available
Glick Skin Institute - Margate
Margate, Florida 33063-7011
United StatesSite Not Available
San Marcus Research Clinic, Inc - Miami
Miami Lakes, Florida 33014
United StatesSite Not Available
Savin Medical Group LLC
Miami Lakes, Florida 33014
United StatesSite Not Available
Oceanic Research Group
North Miami Beach, Florida 33169
United StatesSite Not Available
LENUS Research
Sweetwater, Florida 33172
United StatesSite Not Available
Caban Skin Institute
Tampa, Florida 33607
United StatesSite Not Available
ForCare Medical Center
Tampa, Florida 33613-1244
United StatesSite Not Available
Skin Care Physicians of Georgia - Warner Robins
Macon, Georgia 31217
United StatesSite Not Available
Velocity Clinical Research, Boise
Meridian, Idaho 83642
United StatesSite Not Available
MetroMed Clinical Trials
Chicago, Illinois 60614-3625
United StatesSite Not Available
Arlington Dermatology
Rolling Meadows, Illinois 60008
United StatesSite Not Available
NorthShore Medical Group - Dermatology - Skokie
Skokie, Illinois 60077-1049
United StatesSite Not Available
Dundee Dermatology
West Dundee, Illinois 60118
United StatesSite Not Available
Dawes Fretzin Clinical Research Group
Columbus, Indiana 47201
United StatesSite Not Available
The South Bend Clinic
South Bend, Indiana 46617
United StatesSite Not Available
Equity Medical - Bowling Green
Bowling Green, Kentucky 42104
United StatesSite Not Available
Velocity Clinical Research at The Dermatology Clinic, Baton Rouge
Baton Rouge, Louisiana 70808
United StatesSite Not Available
Tulane University School of Medicine
New Orleans, Louisiana 70112
United StatesSite Not Available
MetroBoston Clinical Partners
Brighton, Massachusetts 02135
United StatesSite Not Available
Great Lakes Research Group Inc.
Bay City, Michigan 48706
United StatesSite Not Available
Cleaver Dermatology
Kirksville, Missouri 63501-5362
United StatesSite Not Available
OptiSkin
New York, New York 10128-0724
United StatesSite Not Available
Duke University School of Medicine
Durham, North Carolina 27713
United StatesSite Not Available
The Skin Surgery Center for Clinical Research
Winston-Salem, North Carolina 27103
United StatesSite Not Available
The Ohio State University Wexner Medical Center (OSUWMC) - OSU Dermatology East - Columbus
Gahanna, Ohio 43230-5317
United StatesSite Not Available
Dermatologists of Southwestern Ohio, LLC
Mason, Ohio 45040-4520
United StatesSite Not Available
Unity Clinical Research (UCR)
Oklahoma City, Oklahoma 73118
United StatesSite Not Available
Velocity Clinical Research, Medford
Medford, Oregon 97504
United StatesSite Not Available
Oregon Medical Research Center
Portland, Oregon 97201
United StatesSite Not Available
Paddington Testing Company Inc.
Philadelphia, Pennsylvania 19103
United StatesSite Not Available
UPMC Department of Dermatology
Pittsburgh, Pennsylvania 15213
United StatesSite Not Available
Clinical Research Center of the Carolinas
Charleston, South Carolina 29407
United StatesSite Not Available
Coastal Carolina Research Center (CCRC) - North Charleston
North Charleston, South Carolina 29405
United StatesSite Not Available
Health Concepts
Rapid City, South Dakota 57702-9208
United StatesSite Not Available
Discover Dermatology, LLC d/b/a Goodlettsville Dermatology Research
Goodlettsville, Tennessee 37072-2301
United StatesSite Not Available
Discover Dermatology, LLC d/b/a Cumberland Skin Center for Clinical Research under Objective Health
Hermitage, Tennessee 37076
United StatesSite Not Available
UT Health Houston Department of Dermatology
Bellaire, Texas 77401
United StatesSite Not Available
Studies in Dermatology, LLC
Cypress, Texas 77429
United StatesSite Not Available
Reveal Research Institute
Frisco, Texas 75033
United StatesSite Not Available
Austin Institute for Clinical Research - Houston
Houston, Texas 77056
United StatesSite Not Available
Center for Clinical Studies - Texas Medical Center
Houston, Texas 77004
United StatesSite Not Available
Heights Dermatology & Aesthetic Center
Houston, Texas 77008
United StatesSite Not Available
Stride Clinical Research LLC
Sugar Land, Texas 77479
United StatesSite Not Available
University of Utah Health Care - Midvalley Health Center
Murray, Utah 84107
United StatesSite Not Available
Frontier Dermatology
Mill Creek, Washington 98012
United StatesSite Not Available
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