Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs

Inclusion Criteria:

1. Signed and dated informed consent for participation in the trial obtained accordingto International Council for Harmonisation of Technical Requirements ofPharmaceuticals for Human Use (ICH) Good Clinical Practice (GCP), and national/localregulations.

2. Male or female ≥ 18 years of age at the time of signing informed consent.

3. Histological confirmation of locally advanced or metastatic, EGFR-mutant (ex19del orL858R mutations) non-small cell lung cancer (NSCLC) Stage IIIB/C or IV (AJCC 8thedition) not eligible for curative intent surgery or chemoradiation.

4. Part 1&2 Disease progression on a 3rd generation EGFR TKI-based therapy (monotherapyor in combination) received at any prior line of treatment.

5. Tumor mutation profile:

• Part 1 (backfilling component) and Part 2: Presence of C797X and absence of T790Mmutations documented locally (as part of clinical practice) on a sample (blood ortissue) collected after progression on treatment with 3rd generation EGFR TKI.

6. Part 1 (Backfilling component), Part 2: At least one measurable target lesionaccording to RECIST v1.1.

7. Eastern cooperative oncology group (ECOG) performance status 0-1.

8. Adequate organ function as defined below:

• Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L

• Platelets ≥ 75 x 10^9/L

• Hemoglobin ≥ 90 g/L.

• Serum total bilirubin ≤ 1.5 x ULN or ≤ 3.0 × ULN for participants withdocumented Gilbert's syndrome.

• Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3.0 xULN. If the participant has liver metastases, AST and ALT ≤5 × ULN.

• Estimated glomerular filtration rate (GFR) ≥ 50 mL/min by CKD-EPI equation

9. Adequate cardiac function as defined below:

• Mean QT interval corrected for heart rate according to Fridericia's formula (QTcF) value ≤ 470 msec for women and ≤ 450 msec for men and no history of longQT syndrome or risk factors for torsade de pointe.

• Left ventricular ejection fraction (LVEF) ≥ 50% .

• Systolic blood pressure < 150 mmHg and diastolic blood pressure < 100 mmHg

10. Female participants of childbearing potential:

• Negative highly sensitive serum β-HCG test performed within 7 days prior tofirst dose of STX-241 (C1D1) and a negative urine pregnancy test performedprior to C1D1.

• Agreement to use one highly effective contraceptive method (as defined inprotocol and according to local regulations), starting at screening period,throughout the trial and until at least 182 days (i.e. more than 5 estimatedSTX- 241 half-lives (2 days) plus 6 months (180 days)) after the last dose ofSTX-241. If the highly effective method of contraception is a hormonalcontraceptive method, it must be supplemented by one additional effective (barrier) method of contraception.

• Agreement to not donate eggs (ova, oocytes) for the purpose of assistedreproduction during the trial and for a period of 182 days after the last doseof STX-241. Note: a female participant of childbearing potential is a woman who is notpermanently sterilized or not postmenopausal (postmenopausal is defined as 12 monthswith no menses without an alternative medical cause).

11. Male participants/partners with female spouse/partners of childbearing potentialmust agree to take appropriate precautions to avoid fathering a child, i.e.:

• Consistently use a barrier method [e.g., condom with spermicidal foam / gel /film /cream/suppository], and his female partner use a highly effective methodof contraception as defined in protocol and according to local regulations),starting at screening and continuing throughout the trial period and for 92days (ie. more than 5 estimated STX-241 half-lives (2 days) plus 3 months (90days)) after the last dose of STX-241.

• Not donate sperm from Day 1 (first administration of STX-241) until at least 92days after the last dose of STX-241.

NOTE: Other protocol defined inclusion criteria may apply.

Exclusion Criteria:

1. Participant candidate for targeted therapies available to them (such as but notlimited to therapies targeting ALK, BRAF, MET, NTRK, ROS1) as identified by localtesting performed after progression to the last line of systemic therapy.

2. Participant with rapid progressive disease eligible to receive a platinum-basedchemotherapy.

3. Participant unable ingest or digest tablets. This can be caused by any impairedgastrointestinal function or disease, such as for example: ulcerative diseases,malabsorption syndrome, small bowel resection, ileus, etc. or any condition causinguncontrolled nausea, vomiting or diarrhea.

4. History of a primary malignancy other than NSCLC with the exception of:

• Participants with a previous malignancy that completed all anticancer treatmentat least 2 years before signing informed consent and with no evidence ofresidual disease from the prior malignancy at screening.

• Malignancies with a negligible risk of metastasis or death (i.e. 5-year overallsurvival rate > 90%) that are adequately treated - Examples include, but arenot limited to, completely resected basal cell carcinoma and squamous cellcarcinoma of skin, melanoma in situ, curatively treated prostate cancer, breastcancer and early gastric cancer cured by endoscopic mucosal resection orendoscopic submucosal dissection.

5. Spinal cord compression or CNS metastases that are associated with progressiveneurological symptoms or require increasing doses of corticosteroids to control theCNS disease. If a participant requires corticosteroids for management of CNSdisease, the dose must have been stable for 2 weeks prior to enrollment in thetrial.

6. History of hypersensitivity to active or inactive ingredients of STX-241, or drugswith a similar chemical structure or from the same class.

7. Active, bacterial, fungal, or viral infection, including, but not limited to:Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and known Human ImmunodeficiencyVirus (HIV) or Acquired Immunodeficiency Syndrome (AIDS)-related illness,tuberculosis or an infection requiring systemic therapeutic treatment within 2 weeksprior to Day 1 (first administration of STX-241). Note: Participants with known HIV infection are permitted if they have controlledinfection (undetectable viral load [HIV ribonucleic acid polymerase chain reaction (PCR)] and CD4 count >350 either spontaneously or on a stable antiviral regimen).For participants with controlled HIV infection, monitoring will be performed perlocal standards.

8. Positive SARs-CoV-2 or variants of SARs-CoV2 RT-PCR test or suspected to be infectedwith SARs-CoV2 or variants of SARsCoV2 with confirmation pending within 2 weeks offirst dose of STX-241.

9. Impaired cardiovascular function or clinically significant cardiovascular disease (either active or within 6 months prior to signing informed consent), including anyof the following:

• Myocardial infarction, acute coronary syndromes including unstable angina,coronary/peripheral artery bypass graft, coronary angioplasty or stenting.

• Symptomatic congestive heart failure (New York Heart Association ClassificationClass ≥ II).

• Cerebrovascular accident or transient ischemic attack.

• Symptomatic bradycardia, requirement for anti-arrhythmic medication.

• Ongoing cardiac dysrhythmias of NCI-CTCAE Grade ≥2.

10. Uncontrolled intercurrent illness including, but not limited to ongoing or activeinfection or psychiatric illness/social situation that would limit compliance withtrial requirements.

11. Past medical history of Interstitial Lung Disease (ILD), drug-induced ILD, radiationpneumonitis that required steroid treatment, or any evidence of clinically activeILD.

12. Past medical history of Stevens-Jonhson Syndrome (SJS) or Toxic epidermal necrolysis (TEN) or any evidence of clinically active SJS/TEN.

13. Women who are breast feeding.

14. Prior anticancer therapy:

• EGFR-targeted TKI within 7 days prior to the first dose of STX-241.

• Any other systemic anticancer therapy within 28 days or 5 half-lives prior tothe first dose of STX-241, whichever is the shortest, but with a minimum of 14days in all circumstances.

• Radiotherapy to a large field or including a vital organ (including whole brainradiotherapy or stereotactic radiosurgery to brain) within 14 days before thefirst dose of STX-241.

15. Live attenuated vaccine received within 30 days prior to the first dose of STX-241.

16. Any toxicities from prior therapy with a NCI-CTCAE Grade ≥1 at the time of the firstdose of STX-241 (C1D1). Exceptions include alopecia (any grade), fatigue with aGrade ≤2, and peripheral neuropathy with a Grade ≤2.

17. Major surgical procedure within 14 days of the first dose of STX-241 (proceduressuch as central venous catheter placement, tumor needle biopsy, and feeding tubeplacement are not considered major surgical procedures). Sequelae of surgicalprocedures must have resolved, including adequate wound healing, prior to the firstdose of STX-241.

18. Treatment with a prohibited medication or herbal remedy known to be strong CYP1A2 orCYP3A4 inducers, strong CYP1A2 or CYP3A4 inhibitors, sensitive CYP1A2, CYP2B6 andCYP3A4 substrates, sensitive MATE1 and OATP1B1 substrates and proton pump inhibitors (PPI) and H2 antagonists unless discontinued prior to the first administration ofSTX-241 within the following timeframe:

• At least 5 half-lives plus 14 days for strong CYP inducers.

• At least 5 half-lives for CYP inhibitors, CYP/transporter substrates, protonpump inhibitor (PPI) and H2 antagonists.

19. Participation in a clinical trial with administration of an investigational drugwithin 5 half-lives plus 14 days of the investigational drug, before the first doseof STX-241.

20. Any condition for which, in the opinion of the investigator, participation would notbe in the best interest of the participant (e. g, could compromise the participant'swell-being) or would prevent, limit, or confound the protocol-specified assessments.

21. Employee or family member of the investigator or site staff.

NOTE: Other protocol defined exclusion criteria may apply.