Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants

Inclusion Criteria:

1. Clinical diagnosis of acute ischemic stroke with indication for IVT according toapplicable guidelines

2. Time from symptom onset or last known well <12 hours

3. Admission NIHSS of 2 points or more

4. either DOAC ingestion within 48 hours prior to expected timepoint of IVT bolus, orpatient with an ongoing prescription of DOAC, but exact timepoint of last intake notverifiable in the emergency setting. (regardless of whether intravenous thrombolysiswas given) OR DOAC prescription (any intake within the last 7 days) and receivingintravenous thrombolysis

5. Informed consent (if obtainable and in those international sites where this islegally required) for the prospective part

Exclusion Criteria:

1. Patient refused the use of biological data for research purposes (Switzerland)

2. Any acute or subacute intracranial hemorrhage (ICH) identified by admission CT orMRI on brain scan

3. Documentation of any other absolute contraindications to IVT in the medical record

4. Significant pre-stroke disability (mRS score of 5), including known advanceddementia

5. Known (serious) sensitivity to Alteplase/Tenecteplase or any of the excipients

6. Pregnancy or lactating women.