Powering Up Stroke Rehabilitation Through HIIT

Phase

N/A

Condition

Cerebral Ischemia

Stroke

Bone Density

Treatment

High-intensity Interval Training

Stretching

Moderate-Intensity Continuous Training

Clinical Study ID

NCT06554665

HSEARS20230720002

Ages 50-80
All Genders

Study Summary

Objectives: To investigate the effects of high-intensity interval training (HIIT) on musculoskeletal fitness in chronic stroke survivors.

Hypothesis to be tested: HIIT, performed on a recumbent stepper, will significantly enhance muscle power in chronic stroke survivors when compared with moderate-intensity continuous training (MICT) Design and subjects: Assessor-blinded, stratified, randomised, placebo-controlled clinical trial involving eligible 66 chronic stroke survivors.

Interventions: Participants will be randomly allocated to one of three groups: the HIIT group, the MICT group, or a stretching group (active control). Each group will attend sessions three times per week for 12 consecutive weeks, totaling 36 training sessions.

Main outcome measures: Assessments will be conducted at baseline, at mid-term of the intervention (week 6), at the end of the intervention (week 12), and at a 12-week follow-up (week 24). The primary outcome measure will be muscle power. Secondary outcome measures will include muscle strength, body composition, biomarkers, motor function, balance function, cardiorespiratory response, and psychosocial response.

Eligibility Criteria

Inclusion

Inclusion criteria:

Men and postmenopausal women aged 50-80 years
1-5 years following the first-ever stroke confirmed by magnetic resonance imaging orcomputed tomography
Able to walk 10 meters independently with or without a walking aid
Class I or II according to the New York Heart Association Functional Classification (no limitation or slight limitation of physical activity due to symptoms duringordinary physical activity)

Exclusion

Exclusion criteria:

Presence of other neurological comorbidities, significant liver or renal diseases,thyroid or parathyroid diseases, rheumatoid arthritis, or a fracture within the past 6 months
Undergoing osteoporosis treatments within the past 3 years, use of oralcorticosteroids for more than 3 months within the past year, or botulinum toxininjections in the paretic lower limb within the past 6 months
Participation in ongoing stroke rehabilitation services or structured exerciseprogramme
Cognitive or communication issues that could limit the ability to followinstructions
Contraindications to HIIT, graded exercise testing, or failure to pass medicalclearance from a specialist

Study Design