Music Perception in SeLECTs

Phase

N/A

Condition

Epilepsy

Treatment

Patients

Clinical Study ID

NCT06545708

69HCL24_0084

Ages 5-14
All Genders

Study Summary

Self-limited epilepsy with centrotemporal spikes (SeLECTS) is the most frequent epilepsy syndrome in children between the ages of 4 and 13 years. SeLECTS is associated in 15 to 30% of patients with specific cognitive deficits, including in particular disorders in language, visuo-spatial memory, declarative memory, and attention. SeLECTS has the potential to evolve into Landau-Kleffner syndrome, the most extreme form of SeLECTS including symptoms of auditory agnosia and aphasia, with potential risks of persistent neuropsychological impairments. In a recent study in adults who had suffered Landau-Kleffner syndrome during childhood, the investigators have shown that these patients, in addition to their known deficit in verbal short-term memory, also exhibit persistent musical difficulties during adulthood, with in particular deficit in melody and rhythm short-term memory.

In the present project, the investigators intend to enlarge the understanding of cognitive deficits generated by SeLECTS in children by investigating the integrity of music perception, both for melody and rhythm. To date, data about music perception in children with epilepsy are scarce and we do not know how distinct components of melody and rhythm perception and memory may be altered.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Subject aged between 5 and 14 years old
Non-opposition of parents or guardians for the child's participation in the study
No major cognitive impairment and ability to understand and apply instructions
Subject affiliated to a social security scheme
Subject motivated to participate in the project
Proficiency with the French language

For the group of control participants:

• Without neurological or psychiatric history

For the group of participants with seizure disorder:

No neurological (except EPCT) or psychiatric history
Diagnosis of self-limited epilepsy with centro-temporal spikes (PTSE) by a qualifiedhealthcare professional.

Exclusion

Exclusion Criteria:

Major cognitive impairment or inability to understand and apply instructions
Individuals refusing to participate in the study
Pregnant or breastfeeding minors

Study Design

Patients

November 13, 2024

November 30, 2026

Study Description

Self-limited epilepsy with centrotemporal spikes (SeLECTS) is the most frequent epilepsy syndrome in children between the ages of 4 and 13 years. The defining electroclinical feature of SeLECTS is the presence of centrotemporal spikes on EEG between seizures. SeLECTS is associated with specific cognitive deficits in 15 to 30% of patients, including disorders in language, visuo-spatial memory, explicit memory, and attention. The centrotemporal spikes are activated in sleep and, in rare cases, the condition has the potential to evolve into an Epileptic Encephalopathy with spike- and- wave activation in sleep (EE-SWAS), including Landau-Kleffner syndrome. The latest is characterized by symptoms of auditory agnosia and aphasia, with potential risks of persistent neuropsychological impairments. In a previous study, it has been shown that these patients also exhibit persistent musical difficulties.

In the present project, the investigators intend to enlarge the understanding of cognitive deficits generated by SeLECTS in children by analyzing the integrity of music perception, both for melody and rhythm, as well as testing the potential of a musical intervention for auditory and cognitive training in children suffering from SeLECTS.

The current research plan is to explore music perception in this specific epilepsy syndrome, with behavioral testing (Experiment 1) and neuroimaging using functional Near-Infrared Spectroscopy (fNIRS) (Experiment 2), and on the long run, informed by this exploration and previous studies, the design of a musical therapeutic intervention is envisioned in order to evaluate the impact of this program on music perception, language, and memory.

Connect with a study center

Centre Hospitalier Le Vinatier (Bât. 452),
Bron, 69500
France
Site Not Available
Hospices Civils de Lyon
Bron, 69500
France
Active - Recruiting

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