Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL

1. Key Inclusion Criteria:

• Aged 18 years old and above

• Histologically confirmed relapsed refractory FL (Module 1) and LBCL (Module 2)after at least 2 prior lines of therapy

• ECOG performance status 0 to 2

• Locally confirmed CD-19 expression in lymphoma cells after progression fromlast CD 19 directed therapy

• FDG-avid disease with at least one bi-dimensionally measurable nodal lesion (defined as > 1.5 cm in its longest dimension), or extranodal lesion (definedas > 1.0 cm in its longest dimension)

• Adequate hematological function: ANC ≥ 1000/mm3, platelets

• 75,000/mm3, hemoglobin ≥ 9 g/dL. Transfusion and/or growth factor areallowed but counts must be stable for at least 72 hours afterwards priorto screening

• Adequate liver function: total bilirubin <1.5x ULN, AST/ALT ≤ 3xULN or < 5 ×ULN in the presence of lymphoma involvement of the liver

• Adequate renal function: creatinine clearance (CrCl) of ≥ 45 mL/min

• Adequate cardiac function, defined as left ventricular ejection fraction (LVEF) ≥ 45% by echocardiogram or MUGA The above is a summary, other inclusion criteria details may apply.

2. Key Exclusion Criteria:

• Diagnosis of CLL, Burkitt lymphoma, or Richter's transformation

• Active CNS involvement by B-NHL

• Leukemic presentation of B-NHL

• History of a clinically relevant CNS medical condition or pathology thatrequired treatment in the preceding year, is currently symptomatic, or that thetreating investigator considers to have the potential to interfere with theevaluation of safety, such as epilepsy, seizure, paresis, aphasia, stroke,severe brain injuries, dementia, neurodegenerative disorder includingParkinson's disease, cerebellar disease, organic brain syndrome, psychosis orother severe mental illness.

• Prior therapy with T-cell engager (TCE) within 8 weeks, autologousHematopoietic Stem Cell Transplantation (HSCT) within 12 weeks, CAR T- celltherapy within 6 months, or prior allogeneic HSCT within 24 weeks of first doseof surovatamig

• Requires chronic immunosuppressive therapy

• Unresolved non hematological AEs ≥ Grade 2 from prior therapies; history of ≥Grade 3 CRS or neurotoxicity from prior CAR-T or TCE therapy

• History of major cardiac abnormalities.

• If female, participant must not be pregnant or breastfeeding.

The above is a summary, other exclusion criteria details may apply.