Evaluation of Two Isometric Exercises in the Reduction of the Blood Pressure in People With Resistant Hypertension

Last updated: July 17, 2024
Sponsor: Universidade do Porto
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vascular Diseases

Williams Syndrome

Circulation Disorders

Treatment

Isometric exercise

Clinical Study ID

NCT06515795
IHGvsIWSinResistantHT
  • Ages 40-75
  • All Genders

Study Summary

Hypertension remains the main preventable cause of cardiovascular disease (CVD) and all-cause mortality, both in Europe and globally. Resistant hypertension, a severe phenotype of hypertension, is defined as a blood pressure (BP) that remains above the management goal despite using three different antihypertensive agents of different classes at the maximum or maximum tolerated dose, or controlled BP on four or more antihypertensive medications. Hypertension remains a poorly controlled risk factor on a global scale and the prevalence of resistant hypertension is also growing - it is now estimated to be around 10-20%.

At the moment, there is robust evidence establishing the antihypertensive effects of exercise. The acute reduction of BP after a single bout of exercise is known as post-exercise hypotension.

In recent years, the number of investigations into the benefits of isometric exercise in the treatment of hypertension has increased, due to its ease of access and potential for use. In a recently published meta-analysis, the authors pointed to isometric exercise as the most effective type of exercise in reducing systolic and diastolic BP.

Given the scarceness of data regarding the safety and efficacy of isometric exercise in individuals with resistant hypertension and since the acute response to exercise may help to identify people who respond to exercise as antihypertensive therapy, the objective of this study is to analyse the acute effect on BP levels of two different isometric exercises - isometric handgrip (IHG) and isometric wall squat (IWS), regarding safety and efficacy, in people with resistant hypertension.

The aim is to analyse if isometric exercises are safe in this population, through the assessment of BP during the execution of the exercises. Besides that, the comparison of IHG and IWS with the control session and between one and another, will help to understand which form of isometric exercise is most effective and has the longest lasting impact on reducing BP.

Each participant must complete an acclimatization session, in which the procedures will be explained, data will be collected and the intensity of IHG and IWS will be assessed. Subsequently, each participant must complete three randomly assigned experimental sessions: a non-exercise control session and two exercise sessions, in which they will follow the protocols currently used in the literature (IHG at 30% of Maximum Voluntary Contraction and IWS at 95% of peak Heart Rate).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults aged 40 to 75 years old, previously diagnosed with resistant hypertension,and on stable medication for at least 6 months.

Exclusion

Exclusion Criteria:

  • People with secondary hypertension, heart failure, peripheral artery disease, atrialfibrillation, chronic obstructive pulmonary disease or renal failure; people with acerebro-cardiovascular event in the previous 3 months; people with changes inpharmacological therapy in the previous 6 months; trained people (with regularparticipation (≥ 2x/week) in exercise training programs in the previous 3 months);people who have any contraindication to exercise; people with neurological and/ ororthopaedic conditions that will interfere with their participation in exercise,such as Parkinson's disease or knee osteoarthritis. Participants with low score (<6)on the MMAS-8 will also be excluded.

Study Design

Total Participants: 15
Treatment Group(s): 1
Primary Treatment: Isometric exercise
Phase:
Study Start date:
July 11, 2024
Estimated Completion Date:
September 30, 2024

Connect with a study center

  • Local Health Unit of the Aveiro Region

    Aveiro,
    Portugal

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.