Evaluation of Monocyte Expression of HLA-DR (mHLA-DR) in Geriatric Service

Inclusion Criteria:

For all patients:

• Patients aged over 75 hospitalised in one of the geriatric units defined as theresearch sites;

• Patient affiliated to a social security scheme;

• Patients or relatives who have been informed and have no objections to the research.

To be eligible in the acute situation sub-population:

• Patients presenting with an acute episode on admission or following a stay in theresearch sites; The acute episode is defined, for example, by an infection, cardiacdecompensation, a complicated fall, acute renal failure, any acute or decompensatedcardiovascular pathology, any discovery of cancer that has not been stabilised.

To be eligible in the stable situation sub-population:

• A patient who has not had an acute episode for at least 7 days.

Exclusion Criteria:

For all patients:

• Patients under legal protection: curatorship, guardianship, safeguard of justice ;

• Patients under exclusive comfort care for whom it has been decided not to take ablood sample;

• Patients undergoing long-term antibiotic treatment, i.e. with no defined stoppingdate;

• An immunocompromised patient or a patient undergoing immunosuppressive treatment (for example: HIV infection, a patient awaiting solid organ transplantation, apatient undergoing haematopoietic stem cell transplantation, a patient undergoingchemotherapy for a solid tumour or haematological malignancy, a patient sufferingfrom an auto-immune disease and being treated with immunotherapy and/orimmunosuppressive therapy and/or biotherapy, an asplenic or hyposplenic patient, apatient undergoing experimental potentially immunosuppressive treatment, a patientundergoing Eculizumab treatment, a patient presenting a hereditary immunedeficiency).

For patients in an acute clinical situation:

• Patient previously included in the same sub-population.