Long-Term Follow-up of Patients Treated With Miltenyi Cell and Gene Therapies

Last updated: November 20, 2025
Sponsor: Miltenyi Biomedicine GmbH
Overall Status: Active - Recruiting

Phase

N/A

Condition

Leukemia

Lymphoma, B-cell

Melanoma

Treatment

MB-CART19.1

MB-CART20.1

MB-CART2019.1

Clinical Study ID

NCT06508775
M-2022-393
2022-501648-14-00
  • All Genders

Study Summary

The goal of this Long-Term Follow-Up Trial is to assess long-term safety and efficacy of Miltenyi CAR T treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient underwent treatment with a Miltenyi CAR T cell therapy in one of the parenttrials at least 12 months prior to enrollment in long-term follow-up.

  • Patient has provided informed consent prior to enrollment.

Exclusion

Exclusion Criteria:

  • No exclusion criteria

Study Design

Total Participants: 40
Treatment Group(s): 3
Primary Treatment: MB-CART19.1
Phase:
Study Start date:
May 05, 2024
Estimated Completion Date:
December 31, 2040

Study Description

The focus in this trial is on the occurrence of any late adverse reactions (AR), serious adverse events (SAE), serious adverse reactions (SAR) and adverse events of special interest (AESI), i.e. relapse or progression of the underlying disease, life-threatening infections, death due to any case, new and secondary malignancies, lymphocyte counts, detection of the transgene of the CAR T cells, detection of replication-competent lentivirus (RCL), developmental tracking in pediatric patients and furthermore, assessment of the primary status of disease progression and overall survival.

Connect with a study center

  • Charité Universitätsmedizin Berlin

    Berlin 2950159, 13353
    Germany

    Active - Recruiting

  • Universitätsklinikum Köln

    Cologne, 50937
    Germany

    Site Not Available

  • Universitätsklinikum Köln

    Cologne 2886242, 50937
    Germany

    Site Not Available

  • Uniklinikum Erlangen

    Erlangen 2929567, 91054
    Germany

    Site Not Available

  • Universitätsmedizin Göttingen

    Göttingen, 37075
    Germany

    Site Not Available

  • Universitätsmedizin Göttingen

    Göttingen 2918632, 37075
    Germany

    Site Not Available

  • Universitätsklinikum Münster

    Münster, 48149
    Germany

    Site Not Available

  • Universitätsklinikum Münster

    Münster 2867543, 48149
    Germany

    Active - Recruiting

  • Universitätsklinikum Tübingen

    Tübingen 2820860, 72076
    Germany

    Site Not Available

  • Universitäts-Kinderklinik Würzburg

    Würzburg, 97080
    Germany

    Site Not Available

  • Universitäts-Kinderklinik Würzburg

    Würzburg 2805615, 97080
    Germany

    Site Not Available

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