Real-world Longitudinal Follow-up Study of a Digital Health Application in Erectile Dysfunction

Inclusion Criteria:

• Men with erectile dysfunction of organic origin (ICD 10 code N48.4) and IIEF-5 score < 21 as determined at therapy start with Kranus EDERA

• Completion of the 12-week app-based therapy with Kranus EDERA

• Improvement in the IIEF-5 score of ≥ 3 points after completion of the Kranus EDERAtherapy compared to the score at the start of the therapy

• Age over 18

Exclusion Criteria:

• Failure to provide informed consent

• Started a new therapy with Kranus EDERA between the end of the last therapy cycleand patient survey

• Started PDE-5 inhibitor treatment during the Kranus EDERA therapy or between the endof the last therapy cycle and patient survey

• Underwent prostatectomy (removal of the prostate gland), radiation or seeds of theprostate gland during the Kranus EDERA therapy or between the end of the lasttherapy cycle and patient survey

• Performed auto-injection therapy (SKAT, MUSE) during the Kranus EDERA therapy orbetween the end of the last therapy cycle and patient survey

• Obtained a penile implant during the Kranus EDERA therapy or between the end of thelast therapy cycle and patient survey

• Underwent major surgery in the small pelvis with probable impairment of theneurovascular supply (e.g., rectum resection, urinary bladder removal) during theKranus EDERA therapy or between the end of the last therapy cycle and patient survey

• Nervous diseases (e.g., multiple sclerosis (MS), Parkinson's disease, stroke,dementia, psychiatric diseases) acquired during the Kranus EDERA therapy or betweenthe end of the last therapy cycle and patient survey

• Developed pronounced circulatory disorders (peripheral arterial occlusive disease)during the Kranus EDERA therapy or between the end of the last therapy cycle andpatient survey

• Trauma involving the pelvis/penis/spine during the Kranus EDERA therapy or betweenthe end of the last therapy cycle and patient survey

• Any other newly developed diseases potentially affecting erectile function (e.g.,leading to a longer period of hospitalization) during the Kranus EDERA therapy orbetween the end of the therapy cycle and patient survey