Inspiring Seniors Towards Exercise Promotion to Protect Cognition

Last updated: March 19, 2025
Sponsor: Emory University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Diabetes Prevention

Treatment

Music

Clinical Study ID

NCT06496425
STUDY00008531
AARF-23-1145107
  • Ages > 65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this clinical trial is to test the benefits of beat-accented music stimulation (BMS) for behavioral changes of physical activity (PA) in older adults with subjective memory complaints. Specific Aims are to determine (1) whether BMS beneficially influences PA behaviors and psychological responses to PA in older adults for 6 months, and (2) whether exercising with BMS differently influences physical and cognitive functioning as well as quality of life in older adults.To test the effects of BMS on PA, participants will be randomly assigned to an exercise intervention that either includes BMS or does not include BMS. Participants will attend a supervised group strength training (ST) (30 min/day) and and aerobic exercise (AE) (30-50 min/day) session for 3 days/week for the first 2 months, 1 day/week for the next 2 months (while encouraging participants to independently perform both AE and ST on other days), and independently for the final 2 months (always with a goal of performing >150min/week AE and 3 days/week of ST for 30 min/day).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults at least 65 years old.

  • Ambulatory/capable of walking for 6 minutes without pain or aid such as awalker/cane.

  • Able to speak and read English.

  • Healthy enough to exercise at moderate intensity with or without medical clearanceby a primary care physician.

  • Living in the community for the duration of the study (6 months).

  • Having a reliable means of transportation.

  • Having a safe place (at least 6 feet by 6 feet of open space) at home forunsupervised exercise training.

  • Having self-perceived memory complaints.

  • Having no symptoms of suicidal ideation and not meeting criteria for depressivedisorder.

  • Physically low-active by doing < 60 min/week of moderate-intensity aerobic exerciseand no strength training for the last 3 months.

Exclusion

Exclusion Criteria:

  • Diagnosis of neurological disorder or spinal cord disorder.

  • Known exercise contraindications.

  • Current cancer treatment.

  • Stroke or neural impairment in the past 6 months.

  • Hip/knee/spinal fracture or surgery in the past 6 month.

  • Unable or unwilling to attend intervention classes 3x/week in Months 1-2 and 1x/weekin Months 3-4.

  • Currently participating in any other physical activity or fitness-related researchstudy.

  • Use of medication for Alzheimer's disease. Change in dosage of medicationsprescribed for anxiety or depression within the previous 6 months.

  • Regularly drink > 14 alcoholic beverages a week or current illicit drug use.

  • Meet the threshold for cognitive impairment.

  • Meet the threshold for clinical depression.

  • Uncorrected hearing or visual impairments.

  • Unable to understand the study procedures.

  • One of the household members is participating in this study.

Study Design

Total Participants: 80
Treatment Group(s): 1
Primary Treatment: Music
Phase:
Study Start date:
May 15, 2024
Estimated Completion Date:
October 31, 2026

Connect with a study center

  • Emory University

    Atlanta, Georgia 30324
    United States

    Active - Recruiting

  • UNC Greensboro

    Greensboro, North Carolina 27412
    United States

    Active - Recruiting

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