Packed Red Blood Cell Transfusion During Cardiac Arrest

Inclusion Criteria:

• Adult patients, age ≥18 and <85 years

• Experience prolonged, non-trauma-related in-hospital cardiac arrest, defined bycessation of heartbeat and respiration requiring CPR for at least 10 minutes

Exclusion Criteria:

• Age <18 years old

• Age > 85 years old

• Patients with DNR/DNI orders (Do Not Resuscitate/Do Not Intubate)

• Patients admitted to the hospital with a cardiac arrest arising from trauma

• Patients who achieve return of spontaneous circulation within 10 minutes of CPR

• Inability to start study product administration within 20 minutes of cardiac arrestonset

• Prisoners

• Women who are known to be pregnant

• Patients with a history of RBC antibodies or positive antibody screen prior toenrollment in the study, unless previously cross-matched units are available fortransfusion.

• Patients with ultrasound evidence of right ventricular dilatation at time of CA

• Patients with known prior objection to receipt of blood products.

• Patients for whom administration of additional fluid volume is contraindicated (asdetermined by physician responsible for care)

• Physician objection based on concern that intervention would interfere with patientcare plan