Study to Evaluate Safety of RTx-015 Injection in Retinitis Pigmentosa or Choroideremia Patients (ENVISION)

Inclusion Criteria:

• Adults ≥18 years of age

• Informed consent obtained from the patient

• Clinical diagnosis of Retinitis Pigmentosa independent of causative mutation ORClinical diagnosis of Choroideremia with known causative mutation

• Study eye and fellow eye Best Corrected Visual Acuity meeting study criteria

• Presence of retinal ganglion cells and/or retinal nerve fiber layer on SpectralDomain Optical Coherence Tomography testing at Screening confirmed by central imagereading center

• Adequate organ function and general good health

Exclusion Criteria:

• Participation in a clinical study (ocular or non-ocular) with an investigationaldrug, agent, or therapy in the past six months

• Concurrent participation in another interventional clinical ocular study

• Prior receipt of any gene therapy (ocular or other), retinal implant, or ocular celltherapy

• Pre-existing eye conditions in either eye that would preclude the planned treatmentor, in the opinion of the Investigator, are significant enough to interfere with theinterpretation of study endpoints or procedural complications

• Known steroid responders if their intraocular pressure was not able to be managedeffectively with topical pressure-lowering medications after prior use of steroidmedications

• Complicating systemic diseases; complicating systemic diseases include those inwhich the disease itself, or the treatment for the disease, can alter ocular and/orCentral Nervous System (CNS) function (e.g., radiation treatment of the orbit;leukemia with CNS/optic nerve involvement)

• Any immunological response dysfunction including, immuno-compromising diseases oruse of immunosuppressive medications, among others

• Cataract or other ocular (including refractive) surgery, intraocular and/orperi-ocular injection in either eye within the prior four months (i.e., 120 days)prior to screening

• Prior vitrectomy or aphakia in the study eye

• Known sensitivity to any component of the study treatment or contraindication tomedications planned for use in the peri-procedural period (e.g., povidone-iodine toprep for intravitreal injection)

• Known contraindication to prophylactic steroid regimen

• Current pregnancy or breastfeeding

• Any other condition that would not allow the patient to complete follow-upexaminations during the study