Blood Pressure Changes After Bariatric Surgery

Last updated: July 15, 2025
Sponsor: Medical University of Warsaw
Overall Status: Completed

Phase

N/A

Condition

Diabetes Prevention

Stress

Circulation Disorders

Treatment

Bariatric surgery - sleeve gastrectomy

Clinical Study ID

NCT06460233
KB/173/2020
  • Ages 18-70
  • All Genders

Study Summary

The aim of the study is to assess changes in blood pressure, cardiac function and selected laboratory measurements after bariatric surgery and to find most important factors associated with blood pressure reduction after weight loss.

Description of the study

Patients: consecutive patients with class III obesity (BMI ≥ 40kg/m2) or class II obesity (BMI 35-40kg/m2) with comorbidities, admitted for sleeve gastrectomy

Methods: bedside and 24-hour blood pressure measurement, cardiac ultrasound and laboratory tests performed before surgery and at 1 week, 4 weeks, 6 months and 12 months after bariatric surgery

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • BMI ≥40kg/m2 or ≥35 kg/m2 with comorbidities

Exclusion

Exclusion Criteria:

  • Lack of informed consent

  • Expected lack of compliance

  • Psychiatric illness

  • Previous bariatric surgery

  • Severe gastroesophageal reflux disease

  • Active neoplastic disease

  • Pregnancy

  • Chronic atrial fibrillation or other persistent arrhythmia

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: Bariatric surgery - sleeve gastrectomy
Phase:
Study Start date:
September 21, 2021
Estimated Completion Date:
June 15, 2025

Study Description

Pathogenesis of blood pressure reduction associated with weight loss is not established. We hypothesize that monitoring of blood pressure changes after weight loss, with concomitant evaluation of cardiac output and selected biochemical parameters related to blood pressure regulation may help in the understanding of weight loss-associated decrease in blood pressure.

The study protocol include measurement of blood pressure (bedside and 24h blood pressure monitoring), assessment of the cardiac function and biochemistry 1-2 days before laparoscopic sleeve gastrectomy and at the time of routine surgical follow-up visits after surgery ie. one week, one month, six and twelve months. Blood pressure measurements will be performed using automatic oscillometric monitors (OnTrak , Spacelabs,USA). Cardiac evaluation will include an echocardiographic assessment of the systolic and diastolic left ventricular function as well as cardiac output measurement using Doppler method. Biochemistry measures, in addition to routine blood tests needed for surgical follow-up, will include fasting insulin, high sensivity C-reactive protein, cystatin C, and NT-proBNP.

Connect with a study center

  • Central Warsaw Medical University Teaching Hospital

    Warsaw, Mazowieckie 02-097
    Poland

    Site Not Available

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