A Study of RSLV-132 in Females With Sjögren's Syndrome

Inclusion Criteria:

• Providing written informed consent

• Weight at least 45 kg

• Meet the 2016 American College of Rheumatology (ACR)/European League AgainstRheumatism (EULAR) Classification Criteria for pSS

• Diagnosis in the last 10 years

• Positive anti-Ro/SSA antibody test

• Score of 5 or higher on the EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI)scale and the ESSPRI fatigue scale

• Of non childbearing potential or of childbearing potential and using highlyeffective contraceptive measures

Exclusion Criteria:

• Diagnosis of any active autoimmune disease other than pSS that could affect theefficacy assessments

• Uncontrolled hypothyroidism or severe fibromyalgia

• New medications or change in medications in the last 4 weeks for pSS symptoms

• Receipt of other prohibited medications

• Apheresis or blood donation

• Allergic reaction to RSLV-132 or biologic therapy

• Clinically significant infection in last 30 days

• Participation in another clinical study

• Malignancy in last 5 years

• Positive test for HIV or hepatitis

• Major surgery in last 30 days or anticipated surgery during the study

• Pregnancy or breast feeding

• Laboratory blood tests outside of specified ranges

• Other medical conditions or medications that would make the participant unsuitable