A Non-interventional, Prospective Study With Benralizumab

Inclusion Criteria:

• Male or female patients aged 18 years or older

• Confirmed diagnosis of severe eosinophilic asthma (defined according to the EuropeanRespiratory Society and American Thoracic Society and local German guidelines)treated with high-dose inhaled corticosteroids (ICS) plus long-acting beta agonists (LABA)

• Prescribed treatment with benralizumab according to label and local marketreimbursement criteria

• Benralizumab treatment was not part of the study decision and treatment decision wasmet prior and independently of the study

• Patients must be able and willing to read and comprehend written instructions

• After full explanation, patients must have signed an informed consent form (ICF)indicating that they understand the purpose of, and the procedures required for thestudy and are willing to participate in the study

• Patients must be willing to report asthma patient-reported outcomes (PROs) every 4weeks and medication intake weekly

Exclusion Criteria:

• Patients who participate in an observational trial that might, in the investigators'opinion, influence the assessment for current study; or participated in a randomizedclinical trial in the last 3 months

• History of anaphylaxis to any biologic therapy

• Prior treatment with any asthma biologic therapy within the last 6 months

• Concurrent asthma biologic therapy

• Helminth parasitic infection diagnosed within 24 weeks prior to the date informedconsent was obtained that had not been treated with, or had failed to respond tostandard of care (SOC) therapy

• Any other pulmonary disease than asthma that, in the investigator's point of view,would have an impact on the interpretation of results

• An acute or chronic condition that, in the investigator's point of view, would limitthe patient's ability to complete questionnaires or participate in this study orimpact the interpretations of results

• Current or history of malignancy within 5 years before the enrolment date with thefollowing exceptions:

• In-situ carcinoma of the cervix where curative therapy has been completed andpatients are in remission for at least 12 months prior to enrolment date

• Basal cell or superficial squamous skin cancer

• Pregnancy or lactation period (status to be proactively asked by the investigator)

• Any condition, that, in the opinion of the investigator, could jeopardize the safetyof the patient