Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms

Inclusion Criteria:

1. Ambulatory, male or female, 21-70 years of age

2. A BMI of 18.5 -34.9

3. . Experiences at least three conditions involving gastrointestinal health on aweekly basis

4. Are comfortable fasting overnight

5. Are able to complete study procedures for up to approximately 6 hours on 2 separatedays

6. Considered to be generally healthy on the basis of medical history

7. Willing to follow study instructions, including compliance with the study proceduresand requirements

Exclusion Criteria:

1. Unable to provide a urine specimen, stool specimen or blood sample from a fingerstick

2. Currently on a galactose/lactose restricted diet

3. Having taken proton pump inhibitors within the past 3 months

4. History of oral antibiotic use within the past 3 months

5. Current or previous history of gastrointestinal disease, cancer, infection orsurgery that may interfere with the outcome parameters

6. A medical or surgical event requiring hospitalization, outpatient visits oremergency room visits within the past 5 years or in the judgment of the StudyInvestigator /Sub-I would preclude participation in the study

7. Current or previous history of diabetes

8. History of a major change in dietary habits with the past 1 month

9. Known intolerance or allergy to sugar alcohols including mannitol, sorbitol,xylitol, lactulose or lactose

10. Women who are lactating, pregnant or planning pregnancy within the next two months

11. Having donated blood or received a blood transfusion within 30 days before screening

12. Currently participating in another clinical research study or participated inanother clinical research study within 30 days prior to screening