RVU120 in Patients With Intermediate or High-risk, Primary or Secondary Myelofibrosis

Inclusion Criteria:

1. Age ≥18 years

2. Diagnosis of Primary or Secondary myelofibrosis (MF) according to the revised WorldHealth Organization (WHO) criteria (Arber 2022).

3. Intermediate or high-risk disease.

4. Resistant or refractory to prior Janus kinase (JAK) inhibitor treatment orineligible for JAK inhibitor treatment in the opinion of the investigator; orSuboptimal response to JAK inhibitor treatment. Note: a suboptimal response to JAKinhibitor treatment is defined as spleen size increase by palpation >25% after thefirst 3 months of treatment with a JAK inhibitor or persistent splenomegaly (spleenvolume of >450 cm3) after at least 6 months of JAK inhibitor treatment and presenceof 1 symptom score ≥5 or 2 symptom scores ≥3, new or persistent red blood cell (RBC)transfusion dependence; or may include participants naïve to previous treatment withJAK inhibitor.

5. Measurable splenomegaly as demonstrated by palpable spleen measuring ≥5 cm below theleft costal margin. The edge of the spleen should be measured from themid-clavicular line on the left side of the abdomen to the point of greatest splenicprotrusion; or spleen volume of ≥450 cm3 measured by magnetic resonance imaging(MRI)or computed tomography (CT).

6. Active symptoms of MF as demonstrated by a symptom score of at least 5 points (on a 0 to 10 scale) on at least one of the symptoms or a score of 3 or greater on atleast 2 of the following symptoms: night sweats, itchiness, abdominal discomfort,pain under ribs on left side, early satiety, bone or muscle pain, and inactivity.

7. Eastern Cooperative Oncology Group (ECOG) performance score 0-2.

8. Adequate hematologic function defined as:

9. absolute neutrophil count (ANC) ≥1.0 × 109/L (without growth factor support)

10. platelet count ≥50 × 109/L (Cohort 2 and Cohort 3 only)

11. Adequate renal function defined as calculated or measured creatinine clearance (CrCl) of ≥30 mL/minute using the formula of Cockcroft and Gault (see Section 15).

12. Adequate liver function defined as (a) aspartate aminotransferase (AST) and alanineaminotransferase (ALT) ≤3 × upper limit of normal (ULN); (b) alkaline phosphatase (ALP) ≤2 × ULN (ALP ≤5 × ULN for participants with isozymes specific to bone); (c)bilirubin <2 × ULN or bilirubin ≤3 × ULN if due to Gilbert's disease.

Exclusion Criteria:

Each participant must not meet any of the following:

1. Peripheral blood blast count of ≥10% or bone marrow blast count of ≥10%.

2. Prior history of hematopoietic stem cell transplant.

3. Participation in any other study in which receipt of an investigational new drugoccurred within 4 weeks prior to Cycle 1 Day 1.

4. Active known second malignancy with the exception of any of the following:

5. Adequately treated basal cell carcinoma, squamous cell carcinoma of the skin,or in situ cervical cancer

6. Adequately treated Stage I cancer from which the participant is currently inremission and has been in remission for ≥2 years

7. Low-risk prostate cancer with a Gleason score <7 and a prostate-specificantigen (PSA) level <10 ng/mL

8. Any other cancer from which the participant has been disease-free for ≥3 years.

9. Known or suspected allergy to RVU120 or RUX.

10. Impairment of gastrointestinal function or gastrointestinal disease

11. Major surgical procedure or significant traumatic injury within 28 days Placement ofa vascular access device or minor surgery is permitted within 14 days before Cycle 1Day 1 (provided that the wound has healed).

12. Ongoing systemic infection requiring antibiotic, antiviral, or antifungal treatment.Note: prophylactic treatment is allowed.

13. Significant cardiac dysfunction defined as myocardial infarction within 12 months ofCycle 1 Day 1, New York Heart Association (NYHA) Class III or IV heart failure,uncontrolled dysrhythmias, poorly controlled angina (Section 17), or leftventricular ejection fraction (LVEF) <40% as per echocardiography or multiple gatedacquisition (MUGA) scan.

14. Taking any medications, herbal supplements, or other substances (including smoking)that are known to be strong inhibitors or moderate/strong inducers or sensitivesubstrates of CYP1A2, within less than 5 half-lives prior to Cycle 1 Day 1.

15. History of ventricular arrhythmia, or QTc ≥470 millisecond (Bazett's formula).

16. Known active human immunodeficiency virus (HIV) infection

17. Current active liver disease from any cause

18. Pregnant or lactating females.

19. Any other prior or current medical or psychiatric condition, intercurrent illness,surgical history, physical or electrocardiogram (ECG) findings, laboratoryabnormalities, or extenuating circumstance (e.g., alcohol or drug addiction) that,in the Investigator's opinion, could jeopardize participant safety or interfere withthe objectives of the study.