Evaluation of Salivary RNA in Subjects Scheduled for Surgery for a Gynecologic Pathology

Inclusion Criteria:

1. Subject of legal age (according to local legislation) and at least 18 years old

2. Subject (and if applicable her legal representative) having dated and signed theinformed consent form

3. Subject with a medical insurance policy

4. Subject presenting to the department:

5. With Symptoms (bleeding and/or pain and/or clinically observed symptom) of oneor more of the following pathologies (suspected undergoing diagnosticsurgery/biopsy or diagnosed and before any curative treatment of thepathology):

• Endometriosis
• Adenomyosis,
• Ovarian cysts,
• Fibroids,
• Ovarian cancer,
• Cervical cancer,
• Uterine cancer.

2. Asymptomatic with pap smear positive for cervical dysplasia or cervical cancerand before any curative treatment.

3. Asymptomatic undergoing a pap smear for cervical cancer screening in agynecological follow-up context.

Exclusion Criteria:

1. Recent (<1 month) or ongoing bacterial or viral infection

2. Known active oral or digestive mycosis

3. Evolving oral pathology, symptomatic or obvious

4. Known pregnancy

5. Known current non-gynecological pelvic pathology

6. Subject with a diagnosed breast cancer or cancer other than gynecological with theexception of basal cell carcinoma

7. Subject with a history of treated cancer within the last 5 years with the exceptionof basal cell carcinoma

8. Subject who has already received chemotherapy or radiotherapy or undergone completeor partial excision of the gynecological pathology of inclusion criterion

9. Subject with significant difficulties reading or writing her language

10. Subject unable to comply with study and/or follow-up procedures

11. Participation in an interventional study with investigational drug or in theexclusion period of an interventional study.