Real-World Clinical Experience of Patients With Metastatic Castration-Resistant Prostate Cancer Treated With Olaparib + Abiraterone (PROceed)

Last updated: April 29, 2025
Sponsor: AstraZeneca
Overall Status: Active - Recruiting

Phase

N/A

Condition

Prostate Cancer

Urologic Cancer

Prostate Cancer, Early, Recurrent

Treatment

N/A

Clinical Study ID

NCT06380738
D0817R00074
D0817R00074
  • Ages > 18
  • Male

Study Summary

PROceed is a multisite, prospective, observational study that describes the real-world use and clinical experience of mCRPC patients treated with the combination of olaparib and abiraterone in the mCRPC setting. Clinical outcomes will be assessed in patients who are either NHA-naive or NHA-exposed prior to initiating olaparib + abiraterone treatment, respectively. Patient demographic and clinical characteristics, as well as treatment received prior and subsequent to olaparib + abiraterone, will also be described. The study plans to enroll patients for a maximum of 2 years and follow up patients from initiation of olaparib until 1 year post last patient in.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Willing and able to provide written informed consent;

  • 18 years of age and above;

  • Documented histopathology or cytopathology of PCa, adenocarcinoma;

  • Confirmed as mCRPC;

  • Initiated olaparib + abiraterone after site activation

Exclusion

Exclusion Criteria:

  • Patients participating in a clinical trial with an investigational prostate cancertreatment within 30 days prior to olaparib initiation

Study Design

Total Participants: 250
Study Start date:
February 14, 2024
Estimated Completion Date:
January 31, 2027

Connect with a study center

  • Research Site

    Aschaffenburg,
    Germany

    Active - Recruiting

  • Research Site

    Augsburg,
    Germany

    Active - Recruiting

  • Research Site

    Bergisch Gladbach,
    Germany

    Active - Recruiting

  • Research Site

    Berlin,
    Germany

    Active - Recruiting

  • Research Site

    Bonn,
    Germany

    Active - Recruiting

  • Research Site

    Dresden,
    Germany

    Active - Recruiting

  • Research Site

    Duisburg,
    Germany

    Active - Recruiting

  • Research Site

    Eisenach,
    Germany

    Active - Recruiting

  • Research Site

    Franckfurt,
    Germany

    Site Not Available

  • Research Site

    Frankfurt,
    Germany

    Active - Recruiting

  • Research Site

    Greifswald,
    Germany

    Active - Recruiting

  • Research Site

    Halle,
    Germany

    Site Not Available

  • Research Site

    Halle (Saale),
    Germany

    Active - Recruiting

  • Research Site

    Hamburg,
    Germany

    Active - Recruiting

  • Research Site

    Hannover,
    Germany

    Active - Recruiting

  • Research Site

    Heidelberg,
    Germany

    Active - Recruiting

  • Research Site

    Heinsberg,
    Germany

    Active - Recruiting

  • Research Site

    Herzogenaurach,
    Germany

    Active - Recruiting

  • Research Site

    Koln,
    Germany

    Active - Recruiting

  • Research Site

    Leipzig,
    Germany

    Active - Recruiting

  • Research Site

    Luebeck,
    Germany

    Active - Recruiting

  • Research Site

    Lueneburg,
    Germany

    Site Not Available

  • Research Site

    Luneburg,
    Germany

    Active - Recruiting

  • Research Site

    Lutherstadt Eisleben,
    Germany

    Active - Recruiting

  • Research Site

    M Nster,
    Germany

    Active - Recruiting

  • Research Site

    Magdeburg,
    Germany

    Active - Recruiting

  • Research Site

    Marburg,
    Germany

    Active - Recruiting

  • Research Site

    Muelheim,
    Germany

    Active - Recruiting

  • Research Site

    Muhlheim,
    Germany

    Site Not Available

  • Research Site

    Münster,
    Germany

    Site Not Available

  • Research Site

    N Rnberg,
    Germany

    Active - Recruiting

  • Research Site

    Neunkirchen,
    Germany

    Active - Recruiting

  • Research Site

    Nurnberg,
    Germany

    Site Not Available

  • Research Site

    Nürnberg,
    Germany

    Site Not Available

  • Research Site

    Ruesselsheim,
    Germany

    Active - Recruiting

  • Research Site

    Russelsheim,
    Germany

    Site Not Available

  • Research Site

    Saalfeld,
    Germany

    Active - Recruiting

  • Research Site

    Speyer,
    Germany

    Active - Recruiting

  • Research Site

    Trier,
    Germany

    Active - Recruiting

  • Research Site

    Tuebingen,
    Germany

    Active - Recruiting

  • Research Site

    Westerstede,
    Germany

    Active - Recruiting

  • Research Site

    Wetzlar,
    Germany

    Active - Recruiting

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