Personalised Monitoring of Early and Intermediate Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression

Last updated: May 12, 2025
Sponsor: Medical University of Vienna
Overall Status: Active - Recruiting

Phase

N/A

Condition

Macular Degeneration

Myopic Macular Degeneration

Aging

Treatment

N/A

Clinical Study ID

NCT06351670
1109/2024
  • Ages 55-99
  • All Genders

Study Summary

The goal of this prospective, multinational, multicenter observational study is to to predict conversion of early and intermediate AMD with functional vision to advanced AMD with irreversible loss of vision on an individual-based level over 2 years. The main objectives of this study are:

  • Identify and quantify focal and global alterations in the retina in regard to disease progression.

  • Assess the individual risk of disease progression in intermediate AMD patients converting to advanced AMD based on imaging.

  • Specify the course of disease in regard to the sequence of events that lead to the conversion to advanced AMD

  • Enhance the ability to classify AMD using artificial intelligence in addition to traditional models.

All patients will be followed for 24 months with 6 month intervals to assess clinical changes. Monitoring of disease progression will be performed using the following routine in-vivo imaging procedures:

  • Scanning Laser Fundus Photography

  • Color Fundus Photography (CFP)

  • Optical Coherence Tomography (OCT)

  • Optical Coherence Tomography Angiography (OCTA) Patients will be asked for their medical history. Standard ophthalmic examination, as well as a questionnaire on visual function will be carried out.

No intervention will be performed during the study since no treatment is yet available within Europe. As soon as treatment is approved in the EU, patients in this cohort might receive treatment according to availability in their respective country and standard of care. If treatment will be performed, it will be as standard of care outside the study according to each country's standard of care and by EMA label.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age: 55-99 years old

  • Early or intermediate AMD in at least one eye (drusen > 63 µm and/or any definitehyper- or hypopigmentary abnormalities with or without reticular pseudodrusen)

  • If both eyes are eligible, both eyes will be included in the cohort study.

  • Clear optical media and adequate pupillary dilation for imaging and functionaltesting.

Exclusion

Exclusion Criteria:

  • Any surgical treatment of the eye within 3 months prior to baseline in the study eye

  • History of anti-VEGF treatment in the study eye before baseline

  • History of pseudophakic cystoid macular edema (Irvine Gass Syndrome) in the studyeye

  • History of uncontrolled glaucoma in the study eye (defined as intraocular pressure (IOP) ≥ 25 mmHg despite treatment with IOP lowering medication), or C/D Ratio > 0.9

  • Any concurrent intraocular condition in the study eye (e.g. advanced cataract ormoderate/severe diabetic retinopathy) that, in the opinion of the investigator, willmost likely require medical or surgical intervention during the study period toprevent or treat visual loss that might result from that condition

  • Any concurrent intraocular condition in the study eye that, in the opinion of theinvestigator, could cause an unwanted effect on treatment efficacy, compliance orrequire intraocular surgery (except for cataract surgery and YAG capsulotomy) duringthe study period

  • Presence of corneal decompensation, haze or scarring with an impact on BCVA

  • Refractive error larger than 6 diopters. In case of pseudophakia or refractivesurgery: History of refractive error larger than 6 diopters.

  • Intake of drugs known to cause retinal toxicity (e.g. hydroxychloroquine ortamoxifen)

  • Presence of active macular neovascularization at baseline

Study Design

Total Participants: 500
Study Start date:
February 25, 2025
Estimated Completion Date:
July 31, 2027

Connect with a study center

  • Medical University of Vienna

    Vienna, 1090
    Austria

    Site Not Available

  • CHU Dijon

    Dijon,
    France

    Active - Recruiting

  • University Medical Center Ljubljana

    Ljubljana,
    Slovenia

    Active - Recruiting

  • Fundacio de Recerca Clinic Barcelona-Institut D Investigacions Biomed

    Barcelona,
    Spain

    Active - Recruiting

  • Vista Klinik Binningen

    Binningen,
    Switzerland

    Active - Recruiting

  • University of Zürich

    Zürich,
    Switzerland

    Active - Recruiting

  • Queen's Unviversity Belfast

    Belfast,
    United Kingdom

    Active - Recruiting

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