Phase
Condition
Hypertriglyceridemia
Treatment
Placebo
Plozasiran Injection
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Established diagnosis of hypertriglyceridemia (HTG) and prior documented evidence (medical history) of mean fasting TG level ≥150 mg/dL (≥1.69 mm/L) and ≤499 mg/dL (≤5.64 mmol/L)
Mean fasting TG level ≥150 mg/dL (≥1.69 mmol/L) and ≤499 mg/dL (≤5.64 mmol/L)collected at 2 separate and consecutive visits at least 7 days apart and no morethan 17 days apart during the screening period
Fasting low density lipoprotein-cholesterol (LDL-C) ≤ 130 mg/dL (≤3.37 mmol/L) atscreening
Screening HbA1c ≤9%
Willing to follow diet counseling and maintain a stable low-fat diet
Must be on standard of care lipid and TG-lowering medications per local guidelines (unless documented as intolerant as determined by the Investigator, including aninability to safely administer or re-administer a specific drug because of fear,preference, genetic, clinical, or metabolic considerations, or due a previousadverse reaction associated with, attributed to, or caused by specific drug) priorto collection of qualifying TG levels.
Exclusion
Exclusion Criteria:
Use of any hepatocyte-targeted small interfering ribonucleic acid (siRNA) thattargets lipids and/or triglycerides within 365 days before Day 1 (except inclisiran,which is permitted). Administration of investigational drug and inclisiran must beseparated by at least 4 weeks.
Use of any other hepatocyte targeted siRNA or antisense Oligonucleotide moleculewithin 60 days or within 5-half-lives before Day 1 based on plasma pharmacokinetics (PK), whichever is longer
Acute pancreatitis within 4 weeks prior to screening
Body mass index >45 kg/m^2
Note: Additional Inclusion/Exclusion criteria may apply per protocol
Study Design
Connect with a study center
Centro Privado de Medicina Familiar - Mind Out Research
Caba, Buenos Aires 1417
ArgentinaSite Not Available
Expertia S.A- Mautalen Salud e Investigación
Caba, Buenos Aires 1128
ArgentinaSite Not Available
Glenny Corp. S.A.
Ciudad Autonoma de Buenos Aires, Buenos Aires C1430CKE
ArgentinaSite Not Available
Centro Medico Luquez
Córdoba, Cordoba 5006
ArgentinaSite Not Available
Sanatorio Privado Duarte Quiroz De Clinica Colombo SA
Córdoba, Cordoba 5000
ArgentinaSite Not Available
CIPADI
Godoy Cruz, Mendoza 5501
ArgentinaSite Not Available
Instituto CAICI
Rosario, Santa Fe 2000
ArgentinaSite Not Available
Instituto de Investigaciones Clinicas de Rosario
Rosario, Santa Fe 2000
ArgentinaSite Not Available
Paratus Clinical Research, Western Sydney
Blacktown, New South Wales 2148
AustraliaSite Not Available
The Aim Centre
Merewether, New South Wales 2291
AustraliaSite Not Available
Monash Medical Centre
Clayton, Victoria 3168
AustraliaSite Not Available
Austin Health
Heidelberg, Victoria 3084
AustraliaSite Not Available
MHAT Puls AD
Blagoevgrad, 2700
BulgariaSite Not Available
Medical Center 4LIFE EOOD
Burgas, 8000
BulgariaSite Not Available
MHAT Yuliya Vrevska - Byala, EOOD
Byala, 7100
BulgariaSite Not Available
Medical Center Diamedical - 2013 OOD
Dimitrovgrad, 6400
BulgariaSite Not Available
MHAT-Haskovo, AD
Haskovo, 6300
BulgariaSite Not Available
Medical Center Hera - Kyustendil
Kyustendil, 2500
BulgariaSite Not Available
MHAT Heart and Brain - Pleven
Pleven, 5800
BulgariaSite Not Available
Medical Center Medconsult Pleven OOD
Pleven, 5800
BulgariaSite Not Available
MHAT Sv. Karidad, EAD
Plovdiv, 4004
BulgariaSite Not Available
UMHAT Kaspela, EOOD
Plovdiv, 4001
BulgariaSite Not Available
UMHAT Pulmed OOD
Plovdiv, 4002
BulgariaSite Not Available
MC Rusemed ltd.
Ruse, 7013
BulgariaSite Not Available
Medical Center Unimed EOOD
Sevlievo, 5400
BulgariaSite Not Available
Diagnostic Consultation Center CONVEX EOOD
Sofia, 1680
BulgariaSite Not Available
MHAT Lyulin EAD
Sofia, 1336
BulgariaSite Not Available
MHAT Sv. Sofia, OOD
Sofia, 1618
BulgariaSite Not Available
Medical Center 'Acad. I. Penchev', EOOD
Sofia, 1431
BulgariaSite Not Available
Medical Center Hera EOOD
Sofia, 1510
BulgariaSite Not Available
Medical Center Kalimat
Sofia, 1680
BulgariaSite Not Available
Medical Center Sv. Dimitar
Sofia, 1616
BulgariaSite Not Available
Second Medical Center
Sofia, 1202
BulgariaSite Not Available
UMHAT Alexandrovska EAD
Sofia, 1431
BulgariaSite Not Available
UMHAT SofiaMed, OOD
Sofia, 1750
BulgariaSite Not Available
UMHAT Sveta Ekaterina
Sofia, 1431
BulgariaSite Not Available
UMHAT Tsaritsa Ioanna ISUL Cardiology clinic
Sofia, 1527
BulgariaSite Not Available
UMHAT Tsaritsa Yoanna - ISUL EAD
Sofia, 1527
BulgariaSite Not Available
Medical Center ZARA-MED EOOD
Stara Zagora, 6010
BulgariaSite Not Available
Medical Arts Health Research Group
North Vancouver, British Columbia V7M 2H4
CanadaSite Not Available
Discovery Clinical Services Ltd.
Victoria, British Columbia V8T 5G4
CanadaSite Not Available
Centricity Research Brampton
Brampton, Ontario L6S 0C6
CanadaSite Not Available
Bluewater Clinical Research Group Inc.
Sarnia, Ontario N7T 4X3
CanadaSite Not Available
Clinical Research Solutions Inc.
Waterloo, Ontario N2T0C1
CanadaSite Not Available
Ecogene-21
Chicoutimi, Quebec G7H 7K9
CanadaSite Not Available
Centre de Recherche Clinique de Laval
Laval, Quebec H7T 2P5
CanadaSite Not Available
Institut De Recherche Clinique De Montreal
Montréal, Quebec H2W 1R7
CanadaSite Not Available
Centre de Medicine Metabolique de Lanaudiere
Québec, Quebec J6X 4P7
CanadaSite Not Available
Clinique des Maladies Lipidiques de Quebec
Québec, Quebec G1V 4W2
CanadaSite Not Available
Nova Scotia Health Authority
Halifax, B3H 1V7
CanadaSite Not Available
Recherche Clinique Sigma Inc
Quebec, G1G 3Y8
CanadaSite Not Available
Institut klinicke a experimentalni mediciny
Praha 4, Prague 140 21
CzechiaSite Not Available
Fakultni nemocnice u svate Anny v Brne, I. Interni kardioangiologicka klinika
Brno, 602 00
CzechiaSite Not Available
CTC Hodonin s.r.o.
Hodonín, 69501
CzechiaSite Not Available
Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05
CzechiaSite Not Available
EDUMED, s.r.o.
Náchod, 547 01
CzechiaSite Not Available
PreventaMed s.r.o.
Olomouc, 779 00
CzechiaSite Not Available
CCR Ostrava s.r.o.
Ostrava, 702 00
CzechiaSite Not Available
MUDr. Jan KVASNICKA CSc.
Praha 10, 101 00
CzechiaSite Not Available
Fakultni Thomayerova nemocnice
Praha 4-Krc, 140 59
CzechiaSite Not Available
Nemocnice Slany
Slaný, 27401
CzechiaSite Not Available
Unilabs Diagnostics, k.s
Teplice, 41501
CzechiaSite Not Available
Kardiologicka ambulance MUDr. Ferkl s.r.o.
Trutnov, 541 01
CzechiaSite Not Available
MEDICAL PLUS s.r.o.
Uherské Hradiště, 686 01
CzechiaSite Not Available
Krajska zdravotni a.s. - Masarykova nemocnice v Usti nad Labem o.z.
Ústí Nad Labem, 40113
CzechiaSite Not Available
Assistance Publique Hopitaux de Marseille AP HM Hopital de La Conception
Marseille, Bouches du Rhone 13005
FranceSite Not Available
Groupe Hospitalier Sud Hôpital Haut-Lévêque
Pessac, Gironde 33604
FranceSite Not Available
Centre Hospitalier Saint Joseph Saint Luc
Lyon, Rhone 69007
FranceSite Not Available
APHP Hôpital Universitaire Pitié Salpêtrière
Paris, 75013
FranceSite Not Available
Gemeinschaftspraxis Dres. Jung
Deggingen, Baden Wuerttemberg
GermanySite Not Available
Gemeinschaftspraxis Dr. Josef Grosskopf und Dr. Wilma Grosskopf
Wallerfing, Bayern 94574
GermanySite Not Available
SMO.MD GmbH
Magdeburg, Sachsen Anhalt 39120
GermanySite Not Available
Belvaros-Lipotvaros Egeszsegugyi Szolgalat
Budapest, 1051
HungarySite Not Available
Clinexpert Kft.
Budapest, 1033
HungarySite Not Available
Privat Doktor Zrt.
Budapest, 1132
HungarySite Not Available
UNO Medical Trials Kft.
Budapest, 1152
HungarySite Not Available
Belgyogyaszati es Kardiologiai Maganrendelo
Békéscsaba, 5600
HungarySite Not Available
Obudai Egeszsegugyi Centrum Kft.
Kaposvar,
HungarySite Not Available
IPR Hungary Kft.
Miskolc, 3530
HungarySite Not Available
COROMed-SMO Kft.
Pécs, 7623
HungarySite Not Available
Da Vinci Magánklinika
Pécs, 7635
HungarySite Not Available
Szegedi Tudományegyetem Szent-Gyorgyi Albert Klinikai Kozpont
Szeged, 6725
HungarySite Not Available
Minoseg Orvoscsoport Kft
Veszprém, 8200
HungarySite Not Available
Belvarosi Egeszseghaz Kft.
Zalaegerszeg, 8900
HungarySite Not Available
IRCCS Istituto Clinico Humanitas
Rozzano, Milano 20089
ItalySite Not Available
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
Palermo, Sicily 90127
ItalySite Not Available
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS
Bologna, 40138
ItalySite Not Available
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia - Presidio Spedali Civili
Brescia, 25123
ItalySite Not Available
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
Milano, 20162
ItalySite Not Available
MICS Centrum Medyczne Bydgoszcz
Bydgoszcz, 85-065
PolandSite Not Available
NZOZ Centrum Medyczne KERmed
Bydgoszcz, 85-065
PolandSite Not Available
Centrum Kliniczno - Badawcze J. Brzezicki B. Gornikiewicz-Brzezicka Lekarze Społka Partnerska
Elbląg, 82-300
PolandSite Not Available
Centrum Medyczne Pratia Gdynia
Gdynia, 81-338
PolandSite Not Available
Clinical Medical Research Sp. z o.o.
Katowice, 40-156
PolandSite Not Available
Krakowskie Centrum Medyczne
Kraków, 31-501
PolandSite Not Available
Pratia MCM Krakow
Kraków, 30-727
PolandSite Not Available
Centrum Badawcze Panaceum Agnieszka Brzezicka Magdalena Lenkiewicz Sp z o.o.
Malbork, 82-200
PolandSite Not Available
Twoja Przychodnia-Szczecinskie Centrum Medyczne
Szczecin, 71-500
PolandSite Not Available
Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu
Toruń, 87-100
PolandSite Not Available
FutureMeds Targowek
Warsaw, 03-291
PolandSite Not Available
FutureMeds Warszawa Centrum
Warsaw, 00-215
PolandSite Not Available
CM Sedimed Wroclaw
Wrocław, 53-030
PolandSite Not Available
FutureMeds Wroclaw
Wrocław, 53-673
PolandSite Not Available
NZOZ Zdrowie s.c. Agnieszka i Donald Drożdż
Wrocław, 51-314
PolandSite Not Available
Velocity Zamosc
Zamość, 22-400
PolandSite Not Available
FutureMeds Lodz
Łódź, 91-363
PolandSite Not Available
Indywidualna Specjalistyczna Praktyka Lekarska
Łódź, 94-255
PolandSite Not Available
Centrum Medyczne Serafin med
Żarów, 58-130
PolandSite Not Available
Kardiointerna s r o
Banská Bystrica, 97401
SlovakiaSite Not Available
Alian s.r.o.
Bardejov, 8501
SlovakiaSite Not Available
Kardiologická ambulancia Cliniq s.r.o.
Bratislava, 81109
SlovakiaSite Not Available
Kardiovaskularne centrum, s.r.o.
Bratislava, 83101
SlovakiaSite Not Available
Kardiologicka a interna ambulancia
Košice, 040 01
SlovakiaSite Not Available
Kardiologicka ambulancia MEDI MandM s.r.o.
Moldava Nad Bodvou, 045 01
SlovakiaSite Not Available
Kardiologicka ambulancia Cardioamb s.r.o.
Nové Zámky, 94002
SlovakiaSite Not Available
Medispol s.r.o.
Prešov, 8001
SlovakiaSite Not Available
Tatratrial s.r.o.
Roznava, 4801
SlovakiaSite Not Available
Dr IO Ebrahim Inc
Centurion, Gauteng 0157
South AfricaSite Not Available
DJW Research
Krugersdorp, Gauteng 1739
South AfricaSite Not Available
Diabetes Care Centre
Pretoria, Gauteng 0181
South AfricaSite Not Available
Dr Jeevren Reddys Surgery
Durban, KwaZulu-Natal 4449
South AfricaSite Not Available
Corbod Research PTY Ltd
Cape Town, Western Cape 7500
South AfricaSite Not Available
Groote Schuur Hospital Lipid Laboratory
Cape Town, Western Cape 7925
South AfricaSite Not Available
Langeberg Clinical Trials
Cape Town, Western Cape 7550
South AfricaSite Not Available
Tiervlei Trial Centre
Cape Town, Western Cape 7530
South AfricaSite Not Available
Dr JM Engelbrecht Trial Site
Somerset West, Western Cape 7130
South AfricaSite Not Available
RYEXO Clinical Research
Pretoria, 0184
South AfricaSite Not Available
Complejo Hospitalario Universitario A Coruña
A Coruña, La Coruña 15006
SpainSite Not Available
Hospital Quironsalud Barcelona
Barcelona, 08023
SpainSite Not Available
Hospital Universitari Vall d'Hebron
Barcelona, 08035
SpainSite Not Available
Hospital Universitario 12 de Octubre
Madrid, 28041
SpainSite Not Available
Hospital Clinico Universitario de Valencia
Valencia, 46010
SpainSite Not Available
Hospital Universitario Miguel Servet
Zaragoza, 50009
SpainSite Not Available
Knowle House Surgery
Plymouth, Devon PL5 3JB
United KingdomSite Not Available
Barts Health NHS Trust
London, EC1M 6BQ
United KingdomSite Not Available
Ascension St. Vincents Birmingham
Birmingham, Alabama 35205
United StatesSite Not Available
IMC Diagnostic and Medical Clinic, LLC
Mobile, Alabama 36604
United StatesSite Not Available
National Heart Institute
Beverly Hills, California 90211
United StatesSite Not Available
Hope Clinical Research
Canoga Park, California 91303
United StatesSite Not Available
National Institute of Clinical Research
Garden Grove, California 92844
United StatesSite Not Available
National Institute of Clinical Research, Inc.
Huntington Beach, California 92648
United StatesSite Not Available
Orange County Research Center, Inc.
Lake Forest, California 92630
United StatesSite Not Available
Clinical Trials Research
Lincoln, California 95648
United StatesSite Not Available
VA Long Beach Healthcare System
Long Beach, California 90822
United StatesSite Not Available
Catalina Research Institute, LLC
Montclair, California 91763
United StatesSite Not Available
Fomat Medical Research, Inc.
Oxnard, California 93030
United StatesSite Not Available
Velocity Clinical Research, Panorama City
Panorama City, California 91402
United StatesSite Not Available
The Cardiovascular Center
Redding, California 96001
United StatesSite Not Available
Legacy Clinical Trials
Colorado Springs, Colorado 80909
United StatesSite Not Available
Innovative Research of West Florida, Inc.
Clearwater, Florida 33756
United StatesSite Not Available
Neoclinical Research
Hialeah, Florida 33016
United StatesSite Not Available
East Coast Institute for Research, LLC
Lake City, Florida 32055
United StatesSite Not Available
Panax Clinical Research
Miami Lakes, Florida 33014
United StatesSite Not Available
Adult Medicine of Lake County
Mount Dora, Florida 32757
United StatesSite Not Available
Harmony Clinical Research, Inc.
North Miami, Florida 33162
United StatesSite Not Available
Florida Institute for Clinical Research
Orlando, Florida 32825
United StatesSite Not Available
Baptist Hospital Cardiology
Pensacola, Florida 32503
United StatesSite Not Available
Cardiovascular Center of Sarasota Foundation for Research and Education
Sarasota, Florida 34239
United StatesSite Not Available
TBC Research
Tamarac, Florida 33321
United StatesSite Not Available
Georgia Clinical Research Center, Inc.
Lawrenceville, Georgia 30044
United StatesSite Not Available
East Coast Institute For Research, LLC
Macon, Georgia 31210
United StatesSite Not Available
Meridian Clinical Research, LLC
Savannah, Georgia 31406
United StatesSite Not Available
RNA America Health Sciences
Sugar Hill, Georgia 30518
United StatesSite Not Available
Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
United StatesSite Not Available
Midwest Cardiovascular Research and Education Foundation
Elkhart, Indiana 46514
United StatesSite Not Available
Ascension St. Vincent Heart Center
Indianapolis, Indiana 46290
United StatesSite Not Available
The South Bend Clinic LLC
South Bend, Indiana 46617
United StatesSite Not Available
Midwest Heart & Vascular Specialists
Overland Park, Kansas 66211
United StatesSite Not Available
Cotton-O'Neil Clinical Research Center, Stormont-Vail West
Topeka, Kansas 66606
United StatesSite Not Available
University of Louisville Research Foundation
Louisville, Kentucky 40202
United StatesSite Not Available
Southern Clinical Research
Metairie, Louisiana 70001
United StatesSite Not Available
Annapolis Internal Medicine
Annapolis, Maryland 21401
United StatesSite Not Available
Ascension Saint Agnes Heart Care
Baltimore, Maryland 21229
United StatesSite Not Available
Elite Clinical Research Center
Flint, Michigan 48532
United StatesSite Not Available
University of Minnesota Medical Center
Minneapolis, Minnesota 55455
United StatesSite Not Available
Olive Branch Family Medical Center
Olive Branch, Mississippi 38654
United StatesSite Not Available
Jefferson City Medical Group PC
Jefferson City, Missouri 65109
United StatesSite Not Available
St. Louis Heart and Vascular
Saint Louis, Missouri 63136
United StatesSite Not Available
Velocity Clinical Research
Norfolk, Nebraska 68701
United StatesSite Not Available
Methodist Physicians Clinic Heart Consultants
Omaha, Nebraska 68114
United StatesSite Not Available
Midwest Regional Health Services LLC
Omaha, Nebraska 68144
United StatesSite Not Available
Santa Rosa Medical Centers of Nevada
Las Vegas, Nevada 89119
United StatesSite Not Available
Overlook Medical Center
Summit, New Jersey 07901
United StatesSite Not Available
CHEAR Center LLC
Bronx, New York 10455
United StatesSite Not Available
Jack D Weike Hospital
Bronx, New York 10461
United StatesSite Not Available
CTSI Investigational Pharmacy
New York, New York 10016
United StatesSite Not Available
Icahn School of Medicine at Mount Sinai
New York, New York 10029
United StatesSite Not Available
Northwell Health Physician Partners at Peconic
Riverhead, New York 11901
United StatesSite Not Available
University of Rochester - PARENT
Rochester, New York 14642
United StatesSite Not Available
Velocity Clinical Research-Vestal New York
Vestal, New York 13850
United StatesSite Not Available
Triad Internal Medicine
Asheboro, North Carolina 27203
United StatesSite Not Available
Carteret Medical Group
Morehead City, North Carolina 28557
United StatesSite Not Available
Wilmington Health
Wilmington, North Carolina 28412
United StatesSite Not Available
Wake Forest University Health Sciences, Department of Cardiology
Winston-Salem, North Carolina 27157
United StatesSite Not Available
Internal Medicine Care Inc
Beavercreek, Ohio 45431
United StatesSite Not Available
University of Cincinnati College of Medicine
Cincinnati, Ohio 45267
United StatesSite Not Available
OhioHealth Research Institute
Columbus, Ohio 43214
United StatesSite Not Available
The Ohio State University Wexner Medical Center
Columbus, Ohio 43210
United StatesSite Not Available
Lynn Institute of Norman
Norman, Oklahoma 73072
United StatesSite Not Available
Lynn Health Sci. Inst.
Oklahoma City, Oklahoma 73112
United StatesSite Not Available
Lynn Health Science Institute East
Oklahoma City, Oklahoma 73111
United StatesSite Not Available
Abington Medical Specialists, P.C.
Horsham, Pennsylvania 19044
United StatesSite Not Available
Capital Area Research, LLC
Newport, Pennsylvania 17074
United StatesSite Not Available
University of Pennsylvania
Philadelphia, Pennsylvania 19104
United StatesSite Not Available
Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania 18711
United StatesSite Not Available
Piedmont Research Partners
Fort Mill, South Carolina 29707
United StatesSite Not Available
Tribe Clinical Research, LLC
Greenville, South Carolina 29607
United StatesSite Not Available
University Diabetes and Endocrine Consultants
Chattanooga, Tennessee 37411
United StatesSite Not Available
Cardiovascular Research Center of Knoxville
Powell, Tennessee 37849
United StatesSite Not Available
David Turbay, MD, PLLC
El Paso, Texas 79905
United StatesSite Not Available
Diabetes and Thyroid Center of Fort Worth
Fort Worth, Texas 76132
United StatesSite Not Available
Baylor College of Medicine
Houston, Texas 77030
United StatesSite Not Available
Clinical Trial Network LLC
Houston, Texas 77074
United StatesSite Not Available
Endocrine and Psychiatry Center
Houston, Texas 77095
United StatesSite Not Available
Gonzalez Research Institute
Houston, Texas 77029
United StatesSite Not Available
Houston Methodist Hospital
Houston, Texas 77030
United StatesSite Not Available
Juno Research LLC
Houston, Texas 77040
United StatesSite Not Available
PlanIt Research, PLLC
Houston, Texas 77079
United StatesSite Not Available
Spring Clinical Research
Houston, Texas 77090
United StatesSite Not Available
Synergy Groups Medical LLC
Houston, Texas 77087
United StatesSite Not Available
Andres Garcia Zuniga MD PA
Laredo, Texas 78041
United StatesSite Not Available
Synergy Groups Medical
Missouri City, Texas 77459
United StatesSite Not Available
Stryde Research
Plano, Texas 75093
United StatesSite Not Available
VIP Trials
San Antonio, Texas 78230
United StatesSite Not Available
Sugar Lakes Family Practice
Sugar Land, Texas 77479
United StatesSite Not Available
Northwest Houston Heart Center
Tomball, Texas 77375
United StatesSite Not Available
Crossroads Clinical Research
Victoria, Texas 77901
United StatesSite Not Available
Cope Family Medicine
Bountiful, Utah 84010
United StatesSite Not Available
Chrysalis Clinical Research, LLC
Saint George, Utah 84790
United StatesSite Not Available
Manassas Clinical Research Center
Manassas, Virginia 20110
United StatesSite Not Available
UW Medicine Diabetes Institute Clinical Research Unit
Seattle, Washington 98109
United StatesSite Not Available
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