Real-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in Germany

Last updated: January 15, 2026
Sponsor: AstraZeneca
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Chest Pain

Congestive Heart Failure

Hyponatremia

Treatment

N/A

Clinical Study ID

NCT06336330
D1699R00050
  • Ages 18-130
  • All Genders

Study Summary

Heart failure (HF) is a global, public health issue that affects more than 63 million people worldwide; this burden is expected to increase substantially as the population ages. Despite advancements in treatment, a HF diagnosis still leads to significant morbidity and mortality; there is also an immense impact on patients' health-related quality of life (HRQoL). Dapagliflozin was recently granted approval for heart failure by the European Commission, regardless of ejection fraction and whether the patient has diabetes. Real-world observational data are necessary to describe dapagliflozin use in real-world settings in order to assess treatment patterns, HF symptoms and their impact on physical limitation, HRQoL and work productivity, as well as health care utilization of patients treated with dapagliflozin in this setting under local treatment standard conditions in Germany.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥18 years as of study index date; the study index date is date of initiation oftreatment with dapagliflozin

  • Patient received/receiving treatment with dapagliflozin in accordance with the localdapagliflozin product label for symptomatic chronic heart failure (HF) and attimepoint of dapagliflozin initiation with:

  • preserved ejection fraction (HFpEF; EF≥50%) OR mildly reduced ejection fraction (HFmrEF; EF 41-49%)

  • OR reduced ejection fraction (HFrEF EF ≤40%)

  • Patient is enrolled within 14 to 90 days following initiation of dapagliflozin

  • Signed and dated informed consent prior to enrolment in the study

Exclusion

Exclusion Criteria:

  • Patient should not be enrolled if he/she is less than 14 days or more than 90 daysfollowing initiation of dapagliflozin

  • Prior treatment with dapagliflozin or other SGLT2i treatment

  • Initiation of dapagliflozin outside of the local HF label

  • Diagnosis of Type 1 diabetes prior to enrolment

  • Current or planned participation in a clinical trial using an investigationalmedical product for treating HF

  • Patient is involved in the planning and/or conduction of the study

  • Hypersensitivity to dapagliflozin or to any of the excipients listed in the SmPC

Study Design

Total Participants: 765
Study Start date:
April 25, 2024
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Research Site

    Aachen, 52062
    Germany

    Site Not Available

  • Research Site

    Aachen 3247449, 52062
    Germany

    Site Not Available

  • Research Site

    Alsfeld, 36304
    Germany

    Site Not Available

  • Research Site

    Alsfeld 2958128, 36304
    Germany

    Site Not Available

  • Research Site

    Bamberg, 96049
    Germany

    Site Not Available

  • Research Site

    Bamberg 2952984, 96049
    Germany

    Site Not Available

  • Research Site

    Bechhofen, 66894
    Germany

    Site Not Available

  • Research Site

    Bechhofen 2951763, 66894
    Germany

    Site Not Available

  • Research Site

    Bergisch Gladbach, 51465
    Germany

    Site Not Available

  • Research Site

    Bergisch Gladbach 2950349, 51465
    Germany

    Site Not Available

  • Research Site

    Berlin, 12489
    Germany

    Site Not Available

  • Research Site

    Berlin 2950159, 12555
    Germany

    Site Not Available

  • Research Site

    Brilon, 59929
    Germany

    Site Not Available

  • Research Site

    Brilon 2944079, 59929
    Germany

    Site Not Available

  • Research Site

    Bruchsal, 76646
    Germany

    Site Not Available

  • Research Site

    Bruchsal 2943560, 76646
    Germany

    Site Not Available

  • Research Site

    Chemnitz, 09113
    Germany

    Site Not Available

  • Research Site

    Chemnitz 2940132, 09113
    Germany

    Site Not Available

  • Research Site

    Dinslaken, 46535
    Germany

    Site Not Available

  • Research Site

    Dinslaken 2936871, 46535
    Germany

    Site Not Available

  • Research Site

    Erfurt, 99097
    Germany

    Site Not Available

  • Research Site

    Erfurt 2929670, 99084
    Germany

    Site Not Available

  • Research Site

    Essen, 45128
    Germany

    Site Not Available

  • Research Site

    Essen 2928810, 45128
    Germany

    Site Not Available

  • Research Site

    Frankenthal, 67227
    Germany

    Site Not Available

  • Research Site

    Frankenthal 2925550, 67227
    Germany

    Site Not Available

  • Research Site

    Gera, 07551
    Germany

    Site Not Available

  • Research Site

    Gera 2921232, 07551
    Germany

    Site Not Available

  • Research Site

    Hamburg, 22087
    Germany

    Site Not Available

  • Research Site

    Hamburg 2911298, 20095
    Germany

    Site Not Available

  • Research Site

    Hoppegarten, 15366
    Germany

    Site Not Available

  • Research Site

    Hoppegarten 2899172, 15366
    Germany

    Site Not Available

  • Research Site

    Kaiserslautern, 67655
    Germany

    Site Not Available

  • Research Site

    Kaiserslautern 2894003, 67655
    Germany

    Site Not Available

  • Research Site

    Kitzingen, 97318
    Germany

    Site Not Available

  • Research Site

    Kitzingen 2890158, 97318
    Germany

    Site Not Available

  • Research Site

    Ludwigsburg, 71634
    Germany

    Site Not Available

  • Research Site

    Ludwigsburg 2875392, 71634
    Germany

    Site Not Available

  • Research Site

    Ludwigshafen am Rhein, 67071
    Germany

    Site Not Available

  • Research Site

    Ludwigshafen am Rhein 2875376, 67071
    Germany

    Site Not Available

  • Research Site

    M Hldorf, 84453
    Germany

    Site Not Available

  • Research Site

    M Nster, 48149
    Germany

    Site Not Available

  • Research Site

    Markkleeberg, 4416
    Germany

    Site Not Available

  • Research Site

    Markkleeberg 2873352, 4416
    Germany

    Site Not Available

  • Research Site

    Meiningen, 98617
    Germany

    Site Not Available

  • Research Site

    Meiningen 2872225, 98617
    Germany

    Site Not Available

  • Research Site

    Muhldorf, 84453
    Germany

    Site Not Available

  • Research Site

    Munster, 48149
    Germany

    Site Not Available

  • Research Site

    Mühldorf, 84453
    Germany

    Site Not Available

  • Research Site

    Münster, 48149
    Germany

    Site Not Available

  • Research Site

    Münster 2867543, 48149
    Germany

    Site Not Available

  • Research Site

    N Rnberg, 90402
    Germany

    Site Not Available

  • Research Site

    Naumburg, 6618
    Germany

    Site Not Available

  • Research Site

    Naumburg 2866906, 6618
    Germany

    Site Not Available

  • Research Site

    Nuremberg 2861650, 90402
    Germany

    Site Not Available

  • Research Site

    Nurnberg, 90402
    Germany

    Site Not Available

  • Research Site

    Nürnberg, 90402
    Germany

    Site Not Available

  • Research Site

    Oschersleben, 39387
    Germany

    Site Not Available

  • Research Site

    Oschersleben 2856930, 39387
    Germany

    Site Not Available

  • Research Site

    Papenburg, 26871
    Germany

    Site Not Available

  • Research Site

    Papenburg 2855525, 26871
    Germany

    Site Not Available

  • Research Site

    Passau, 94032
    Germany

    Site Not Available

  • Research Site

    Passau 2855328, 94032
    Germany

    Site Not Available

  • Research Site

    Pirna, 1796
    Germany

    Site Not Available

  • Research Site

    Pirna 2853572, 01796
    Germany

    Site Not Available

  • Research Site

    Potsdam, 14471
    Germany

    Site Not Available

  • Research Site

    Potsdam 2852458, 14471
    Germany

    Site Not Available

  • Research Site

    Querfurt, 6268
    Germany

    Site Not Available

  • Research Site

    Querfurt 2851393, 06268
    Germany

    Site Not Available

  • Research Site

    Ratingen, 40882
    Germany

    Site Not Available

  • Research Site

    Ratingen 2850174, 40882
    Germany

    Site Not Available

  • Research Site

    Rostock, 18059
    Germany

    Site Not Available

  • Research Site

    Rostock 2844588, 18059
    Germany

    Site Not Available

  • Research Site

    Schleswig, 24837
    Germany

    Site Not Available

  • Research Site

    Schleswig 2838634, 24837
    Germany

    Site Not Available

  • Research Site

    Schw Bisch Hall, 74523
    Germany

    Site Not Available

  • Research Site

    Schwabisch Hall, 74523
    Germany

    Site Not Available

  • Research Site

    Schwandorf, 92421
    Germany

    Site Not Available

  • Research Site

    Schwandorf in Bayern 2835297, 92421
    Germany

    Site Not Available

  • Research Site

    Schwäbisch Hall, 74523
    Germany

    Site Not Available

  • Research Site

    Schwäbisch Hall 2835481, 74523
    Germany

    Site Not Available

  • Research Site

    Siegen, 57072
    Germany

    Site Not Available

  • Research Site

    Siegen 2832495, 57072
    Germany

    Site Not Available

  • Research Site

    Steinfurt, 48565
    Germany

    Site Not Available

  • Research Site

    Steinfurt 2828105, 48565
    Germany

    Site Not Available

  • Research Site

    Stollberg, 09366
    Germany

    Site Not Available

  • Research Site

    Stollberg 2826584, 09366
    Germany

    Site Not Available

  • Research Site

    Straubing, 94315
    Germany

    Site Not Available

  • Research Site

    Straubing 2826099, 94315
    Germany

    Site Not Available

  • Research Site

    Stuttgart, 70178
    Germany

    Site Not Available

  • Research Site

    Stuttgart 2825297, 70178
    Germany

    Site Not Available

  • Research Site

    Ulm, 89073
    Germany

    Site Not Available

  • Research Site

    Ulm 2820256, 89073
    Germany

    Site Not Available

  • Research Site

    Wermsdorf, 04779
    Germany

    Site Not Available

  • Research Site

    Wermsdorf 2810848, 04779
    Germany

    Site Not Available

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