A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer

Inclusion Criteria:

Part I

• Age ≥45 years

• Scheduled visit with a nongynecologic surgeon

• Female or assigned female at birth

Part II

• Age ≥45 years

• At least one in situ fallopian tube

• No desire or plan to have children in the future

• Average risk of developing ovarian cancer

° Note: Average risk patients are defined as patients with no known genetic riskfactor for developing ovarian cancer. Patients who, after obtaining family history,are suspected to have a hereditary ovarian cancer syndrome but have not yet beentested, will be referred for genetic evaluation.

• Planned nongynecologic, intraabdominal, or pelvic surgery

• Deemed to be a suitable candidate by gynecologic surgeon and primary nongynecologicsurgeon (for example, on the basis of surgical history and current malignancystatus)

• Approved and signed informed consent

Exclusion Criteria:

Part I

• Not fluent in English

° If there is a non-english speaking participant who is a strong candidate and meetsall other criteria for Part 2, they are able to go directly onto Part 2 withoutcompleting Part 1. (Please see additional details in section 4.1 and 7.0.)

• Known inherited ovarian cancer susceptibility

Part II

• Personal history of a gynecologic malignancy

• Carrier of a hereditary breast or ovarian cancer variant (e.g., BRCA1, BRCA2, BRIP1,PALB2, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2)

• Suspicious ovarian, fallopian tube, or uterine lesion on preoperative imaging

• Previous bilateral salpingectomy or bilateral salpingo-oophorectomy

• Current pregnancy

• Emergent procedure or emergency procedure that has to be completed within 24 hourswhere clinical consent occurs in the inpatient setting or where the patient'simmediate well-being is in danger or condition may be life threatening

• Primary surgeon anticipates that OS will add significant time (>30-40min) to theplanned procedure.

• Inability to access the pelvis (ex., patient prone/lateral position) during theplanned procedure.

• Known history of pelvic fibrosis or significant adhesions.

• Procedures with palliative intent only